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Journal of Biological Sciences

Year: 2017 | Volume: 17 | Issue: 8 | Page No.: 381-387
DOI: 10.3923/jbs.2017.381.387

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Authors


Shalom Nwodo  Chinedu

Shalom Nwodo Chinedu

LiveDNA: 234.2440

Franklyn Nonso  Iheagwam

Franklyn Nonso Iheagwam

LiveDNA: 234.18474

Chisom Juliet Anichebem

Country: Nigeria

Gbemisola Beatrice Ogunnaike

Country: Nigeria

Opeyemi Christianah  Emiloju

Opeyemi Christianah Emiloju

LiveDNA: 234.18299

Keywords


  • antioxidant
  • Thaumatococcus daniellii
  • biochemical parameters
  • in-vivo effect
  • liver histology
  • liver diseases
Research Article

Antioxidant and Biochemical Evaluation of Thaumatococcus daniellii Seeds in Rat

Shalom Nwodo Chinedu Shalom Nwodo  Chinedu's LiveDNA, Franklyn Nonso Iheagwam Franklyn Nonso  Iheagwam's LiveDNA, Chisom Juliet Anichebem, Gbemisola Beatrice Ogunnaike and Opeyemi Christianah Emiloju Opeyemi Christianah  Emiloju's LiveDNA
Background and Objective: Despite numerous reports of medicinal uses of Thaumatococcus daniellii (T. daniellii) plant, there remains a dearth of information on the in vivo effect of the seed. In this study, the antioxidant and biochemical effects of T. daniellii seeds in the liver and kidney of male wister rats were assessed. Materials and Methods: Seeds were macerated with ethanol and filtrate was concentrated to yield an ethanolic crude extract. Rats were orally dosed with vitamin C, 500, 1000 and 1500 mg kg–1 of the extracts for 14 days. Antioxidant and biochemical parameters were evaluated. Liver histology was examined. Data were subjected to one-way analysis of variance and expressed as Mean±SEM. Results: It was observed that T. daniellii seed reduced the amount of total body weight gain but did not have any effect on organ weight (p<0.05). Treatment also resulted in significant (p<0.05) increase in hepatic SOD and GSH. It was only at the highest dose that renal GSH increased significantly (p<0.05). These antioxidant effects were associated with maintaining bilirubin concentration and reducing AST activity in the liver (p<0.05). Histopathological observations were in correlation with the biochemical results showing that there was no pathologic abnormality. Conclusion: The results of this study indicate that T. daniellii seed is a source of natural antioxidant and may be exploited for the treatment of kidney and liver diseases.
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How to cite this article

Shalom Nwodo Chinedu, Franklyn Nonso Iheagwam, Chisom Juliet Anichebem, Gbemisola Beatrice Ogunnaike and Opeyemi Christianah Emiloju, 2017. Antioxidant and Biochemical Evaluation of Thaumatococcus daniellii Seeds in Rat. Journal of Biological Sciences, 17: 381-387.

DOI: 10.3923/jbs.2017.381.387

URL: https://scialert.net/abstract/?doi=jbs.2017.381.387

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