Research Article

Silk Fibroin/Gelatin Hybrid Films for Medical Applications: Study on Chlorhexidine Diacetate

Simchuer Wilaiwan, Srisuwan Yaowalak, Baimark Yodthong and Srihanam Prasong

This study aimed to prepare silk fibroin (SF)/gelatin (G) hybrid films by a solvent evaporation method for loading chlorhexidine diacetate (CHX). The SF and G solution in different ratios were mixed with CHX and placed on the 5 cm polystyrene plates before drying to obtain hybrid films. The films were determined their secondary structures and thermal properties by using Fourier transform infrared (FT-IR) spectrometer and thermogravimetric analysis (TGA), respectively. The results found that all of film composed of α-helix and β-sheet structures. However, differences of the α-helix and β-sheet structures were differed according to each component. The hybrid films showed soft texture and decreased of brittle compared to SF film only when the G content increased. Thermal properties of the films indicated that decomposition temperature profiles of all films did not differ dramatically, however, combination of characteristics both SF and G were appeared in hybrid films. The releasing rate of CHX-loaded in the films was found that the CHX has released from the SF film in higher rate than hybrid and G films, respectively. It is a promising that polarity, flexibility as well as component ratio of each polymer play important role on the releasing of CHX.

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Simchuer Wilaiwan, Srisuwan Yaowalak, Baimark Yodthong and Srihanam Prasong, 2010. Silk Fibroin/Gelatin Hybrid Films for Medical Applications: Study on Chlorhexidine Diacetate. Journal of Biological Sciences, 10: 455-459.

DOI: 10.3923/jbs.2010.455.459

URL: https://scialert.net/abstract/?doi=jbs.2010.455.459

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Authors

Simchuer Wilaiwan

Srisuwan Yaowalak

Baimark Yodthong

Srihanam Prasong

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Research Article

Silk Fibroin/Gelatin Hybrid Films for Medical Applications: Study on Chlorhexidine Diacetate

How to cite this article

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