Drugs are an important reason of hepatotoxicity. In general more than 900 drugs, toxins and herbs have been reported to cause hepatotoxicity and drugs account for 20-40% of all instances of fulminant hepatic failure. Specific therapy against drug-induced hepatotoxicity is limited to the use of N-acetylcysteine in the early phases of paracetamol toxicity. L-carnitine is potentially valuable in cases of valproate toxicity. In general, corticosteroids have no definitive role in treatment. They may prevent the systemic features associated with hypersensitivity or allergic reactions. Cholestyramine can be used for alleviation of pruritus. Ursodeoxycholic acid may be used. Lastly, consulting a hepatologist is always useful for other agents, supportive measures and the increasing use of liver-assist devices as well as emergency liver transplantation are available when drug injury evolves into irreversible liver failure. It is expected that a better understanding of hepatotoxicity mechanisms will lead to the development of more specific and effective forms of therapy in the near future.