
	Journal of Biological Sciences
	Year: 2008 \| Volume: 8 \| Issue: 2 \| Page No.: 410-415 DOI: 10.3923/jbs.2008.410.415

Canola and Mustard Seeds/Sprouts Reduce the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colon Cancer in Fisher 344 Male Rats

A. Clisby, M. Verghese, E. Cebert, L.T. Walker, R. Field, L. Shackelford, J. Boateng and C.B. Chawan

Abstract: The aim of the current study was to determine the efficacy of selected canola or mustard seeds (S) and canola sprouts (SP) cultivars (5 and 10% levels) on azoxymethane (AOM) induced Aberrant Crypt Foci (ACF) in Fisher 344 male rats. Following a one week period of acclimatization Fisher 344 male rats were randomly assigned to groups (n = 6). At seven and eight weeks of age rats received two successive s/c injections of AOM in saline at 16 mg kg^-1 body weight. Rats were killed by CO₂ asphyxiation at 17 weeks of age. The number of ACF in the proximal and distal colon in the treatment groups ranged from 6.33 (5% Pacific gold) to 15.55 (5% Jetton) and 21.33 (10% Pacific gold) to 52.0 (5% Idagold). Glutathione-S-transferase activity (μmol mg^-1) was significantly (p<0.05) higher in the groups fed canola or mustard seeds compared to the control. Among the treatment groups the highest GST activity (μmol mg^-1) was observed in the rats fed 10% Pacific gold group (32.50). The results from this study show that canola or mustard sprouts and seeds reduced the incidence of AOM-induced ACF and may possibly prevent the incidence of colon cancer.

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RELATED ARTICLES:

•	Selected Cruciferous Vegetables and their Effects on Azoxymethane (AOM) Induced Aberrant Crypt Foci

How to cite this article:

A. Clisby, M. Verghese, E. Cebert, L.T. Walker, R. Field, L. Shackelford, J. Boateng and C.B. Chawan, 2008. Canola and Mustard Seeds/Sprouts Reduce the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colon Cancer in Fisher 344 Male Rats. Journal of Biological Sciences, 8: 410-415.

DOI: 10.3923/jbs.2008.410.415

URL: https://scialert.net/abstract/?doi=jbs.2008.410.415

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