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Journal of Biological Sciences
  Year: 2008 | Volume: 8 | Issue: 7 | Page No.: 1241-1245
DOI: 10.3923/jbs.2008.1241.1245
Histopathologic Effects of Sulfur Dioxide in Mouse Liver Following the Chronic and Acute Exposure
F. Rajaii, A.A. Khaki, A. Khaki, F. Khorshid, N. Borhani, H. Jfraii, H. Haghdust and N. Gheibi

Abstract:
The present study examined the histopathologic effects of this gas on the mouse liver in acute and chronic exposure. Twenty eight male mice were divided into 4 groups. Group 1 (G1) as control ( not exposed to gas ), group 2 (G2) were exposed to high dose of (100 ppm) and group 3 (G3) and group 4 (G4) were exposed to low dose of sulfur dioxide for 5 min for 1 and 3 weeks (20 ppm). Finally the mice were sacrificed and liver were assessed macroscopically and then the biopsy of the liver were assessed microscopically. The data were analyzed statistically. The results showed that the mean number of kupffer cells in G2, G3 and G4 significantly increased (9 ± 1.0, 10 ± 1.0, 11 ± 1.2 vs 7 ± 1.4 and p<0.0001). Qualitative observations also showed significantly increase in the rate of liver cell necrosis and deformation of hepatic cords and sinusoids with an increase of inflammatory reactions in experimental mice. Present study was indicated that the liver can be damaged by the chronic and acute exposure of sulfur dioxide.
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How to cite this article:

F. Rajaii, A.A. Khaki, A. Khaki, F. Khorshid, N. Borhani, H. Jfraii, H. Haghdust and N. Gheibi, 2008. Histopathologic Effects of Sulfur Dioxide in Mouse Liver Following the Chronic and Acute Exposure. Journal of Biological Sciences, 8: 1241-1245.

DOI: 10.3923/jbs.2008.1241.1245

URL: https://scialert.net/abstract/?doi=jbs.2008.1241.1245

 
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