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Journal of Applied Sciences
  Year: 2009 | Volume: 9 | Issue: 11 | Page No.: 2198-2200
DOI: 10.3923/jas.2009.2198.2200
 
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Dimethyl 2-Hydroxy-1-Methyl-3-[2-Oxo-2-Phenylethylidene]-2-Phenyl-1,2-Dihydro-3H-Pyrrole 4,5-Dicarboxylate: A Potential Lead Compound as Anti-Gram-Positive and Anti-Gram-Negative Agent

R. Ramazanzadeh and F. Nasiri

Abstract:
The aim of this study was to determination the biological activity of some new synthesized pyrrole compounds. The activity against Gram-positive and Gram-negative bacteria of dimethyl 2-hydroxy-1-methyl-3-[2-oxo-2-phenylethylidene]-2-phenyl-1,2-dihydro-3H- pyrrole-4,5-dicarboxylate I was tested in vitro using six reference bacterial strains. e.g., Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Escherichia coli, Enterobacter earogenes and Pseudomonas aeruginosa. Compound I was active against all strains tested by disk diffusion method in ranging from 15 to 27 mm per 70 μg disk. In conclusion, this compound might be used as a basic to modification in order to synthesize new antibacterial agents.
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How to cite this article:

R. Ramazanzadeh and F. Nasiri, 2009. Dimethyl 2-Hydroxy-1-Methyl-3-[2-Oxo-2-Phenylethylidene]-2-Phenyl-1,2-Dihydro-3H-Pyrrole 4,5-Dicarboxylate: A Potential Lead Compound as Anti-Gram-Positive and Anti-Gram-Negative Agent. Journal of Applied Sciences, 9: 2198-2200.

DOI: 10.3923/jas.2009.2198.2200

URL: https://scialert.net/abstract/?doi=jas.2009.2198.2200

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