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American Journal of Drug Discovery and Development
  Year: 2012 | Volume: 2 | Issue: 1 | Page No.: 40-49
DOI: 10.3923/ajdd.2012.40.49
 
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Synthesis of Some Pyrrole Derivatives and their Anticoagulant Activity

A. Idhayadhulla, R. Surendra Kumar, A. Jamal Abdul Nasser and Aseer Manilal

Abstract:
New pyrrole derivatives (2,3) were synthesized by condensation method and synthesized compounds were characterized by IR, 1H NMR, 13C NMR, mass and elemental analysis. The novel pyrrole derivatives were screened for anticoagulant activity against Activated Partial Thromboplastin Time (APTT) and Prothrombin Time (PT) coagulation assays and compound (3) is highly response for anticoagulant activity compared with compounds (1) and (2) and standard Heparin at concentration (60 μg mL-1) against APTT assay. The compound 3 showed highly significant anticoagulant effect and could be considered as leads for further investigations.
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How to cite this article:

A. Idhayadhulla, R. Surendra Kumar, A. Jamal Abdul Nasser and Aseer Manilal, 2012. Synthesis of Some Pyrrole Derivatives and their Anticoagulant Activity. American Journal of Drug Discovery and Development, 2: 40-49.

DOI: 10.3923/ajdd.2012.40.49

URL: https://scialert.net/abstract/?doi=ajdd.2012.40.49

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