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International Journal of Pharmacology
  Year: 2022 | Volume: 18 | Issue: 8 | Page No.: 1576-1582
DOI: 10.3923/ijp.2022.1576.1582
 
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Resveratrol Ameliorates Kidney Injury and Fibrosis Secondary to Diabetes in Association with Inflammation and Nitrosative Stress Inhibition in Rats

Maha A. Momenah

Abstract:
Background and Objective: Nephropathy secondary to diabetes is a severe disease that can advance to end-stage renal failure leaving kidney transplant as the only available method of treatment. This study sought to determine whether the plant polyphenolic compound, resveratrol (RSV) can inhibit diabetes-induced kidney fibrosis axis, inflammation/nitrosative stress/collagen in rats. Materials and Methods: Type 2 Diabetes Mellitus (T2DM) was established in rats using a blend of a high-fat diet and a single injection of streptozotocin. Whereas, the protective group of rats was pretreated with RSV suspension (30 mg kg–1) followed by diabetes induction and continued on resveratrol until the scarification day for all the groups, at 12 week. Results: Hyperglycemia, weight loss, high levels of blood creatinine and urea and substantial kidney collagen fibers deposition confirmed diabetic nephropathy development. Also, diabetes significantly (p<0.0001) induced blood and kidney tissue protein expression of (1) Inflammation, Tumour Necrosis Factor-α (TNF-α) and Interleukin-6 (IL-6) and (2) The nitrosative stress marker, Inducible Nitric Oxide Synthase (iNOS) enzyme using immunohistochemistry. All the above-mentioned parameters were inhibited by RSV. Furthermore, a significant correlation was detected between inflammation/iNOS/collagen axis and kidney injury biomarkers. Conclusion: Induction of T2DM for 10 weeks in rats develops nephropathy associated with the induction of inflammation and nitrosative stress, which is protected by resveratrol. This may suggest a likely therapeutic potential in diabetic nephropathy.
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How to cite this article:

Maha A. Momenah , 2022. Resveratrol Ameliorates Kidney Injury and Fibrosis Secondary to Diabetes in Association with Inflammation and Nitrosative Stress Inhibition in Rats. International Journal of Pharmacology, 18: 1576-1582.

DOI: 10.3923/ijp.2022.1576.1582

URL: https://scialert.net/abstract/?doi=ijp.2022.1576.1582

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