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International Journal of Pharmacology

Year: 2018 | Volume: 14 | Issue: 1 | Page No.: 61-67
Research Article

Pharmacological Investigation of Phoenix dactylifera L. in Azithromycin Induced Toxicity

Mobasher Ahmad
Department of Pharmacology, University College of Pharmacy, University of the Punjab, 54000 Lahore, Pakistan
Iqra Masood
Department of Pharmacology, Lahore College of Women University, Lahore Pakistan
Hafeez Ikram
Department of Pharmacology, Lahore College of Women University, Lahore Pakistan
Rukhsana Anwar
Department of Pharmacology, University College of Pharmacy, University of the Punjab, 54000 Lahore, Pakistan
LiveDNA: 92.16634
Afroze Mobasher
Department of Pharmacology, University College of Pharmacy, University of the Punjab, 54000 Lahore, Pakistan
Sairah Hafeez Kamran
Department of Pharmacology, University College of Pharmacy, University of the Punjab, 54000 Lahore, Pakistan
Usman Akhtar
Department of Pharmacology, University College of Pharmacy, University of the Punjab, 54000 Lahore, Pakistan
Background and Objective: Phoenix dactylifera L. (Ajwa dates) is a primeval plant possessing special characteristic in therapeutics. The aim of the current study was to investigate the pharmacological effects of aqueous and methanolic extracts of Phoenix dactylifera L. on liver, lipid and renal parameters in azithromycin treated rabbits. Materials and Methods: Experimental animals were divided into 4 groups (n = 4) group I (Normal rabbits), group II Azithromycin (AZT) (30 mg kg–1 for 7 days), group III Azithromycin+Aqueous extract (AZT-Aqu) AZT 30 mg kg–1 for 7 days daily then aqueous extract of Phoenix dactylifera L. (300 mg kg–1 for 7 days), group IV Azithromycin+Methanolic extract (AZT-Met) AZT 30 mg kg–1 for 7 days daily, then methanolic extract of Phoenix dactylifera L. (300 mg kg–1 for 7 days). The data were analyzed as Mean±SEM. Student’s-test was applied for statistical evaluation by using SPSS version 19. Results: The serum enzyme levels of liver (AST, ALT, LDH and ALP), lipid profile, creatinine and uric acid levels were analyzed for determining treatment effects of Phoenix dactylifera L. Liver function tests, lipid profile, creatinine and uric acid showed (p<0.05) significant decrease and improvement when compared with the group II. The histopathological analysis of liver showed less damage in treated animals. Conclusion: The result of current study concludes that Phoenix dactylifera L. significantly reduces the toxicity induced by azithromycin.
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How to cite this article

Mobasher Ahmad, Iqra Masood, Hafeez Ikram, Rukhsana Anwar, Afroze Mobasher, Sairah Hafeez Kamran and Usman Akhtar, 2018. Pharmacological Investigation of Phoenix dactylifera L. in Azithromycin Induced Toxicity. International Journal of Pharmacology, 14: 61-67.

DOI: 10.3923/ijp.2018.61.67

URL: https://scialert.net/abstract/?doi=ijp.2018.61.67

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