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International Journal of Pharmacology
  Year: 2018 | Volume: 14 | Issue: 3 | Page No.: 391-396
DOI: 10.3923/ijp.2018.391.396
Bactericide, Antioxidant and Cytotoxic Activities from Marine Algae of Genus Laurencia Collected in Baja California Sur, Mexico
Sara Garcia-Davis, Ivan Murillo-Alvarez, Mauricio Munoz-Ochoa, Edith Carranza-Torres, Ruth Garza-Padron, Eufemia Morales-Rubio and Ezequiel Viveros-Valdez

Abstract:
Background and Objective: Marine environment represents countless and diverse resource for new drugs to combat major diseases. Extracts from four Laurencia species (L. johnstonii, L. pacifica, L. gardneri and L. papillosa) from Baja California Sur, Mexico were evaluated for their antioxidant, antibacterial and cytotoxic activity. Methodology: The antioxidants activity of Laurencia sp. were evaluated using the radical scavenging activity in three in vitro radicals: 1,1-Diphenyl-2-picrylhydrazyl (DPPH), 2,2'-Azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and nitric oxide (NO). The antibacterial activity was evaluated by the broth microdilution method to determinate the Minimum Inhibitory Concentrations (MIC) against Staphylococcus aureus, Bacillus subtilis, Enterococcus faecalis, Micrococcus luteus, Pseudomonas aeruginosa and Klebsiella pneumoniae. The cytotoxicity was analyzed on HeLa (cervix adenocarcinoma) and Vero (kidney epithelial) cells, using the reduction of tetrazolium salt WST-1. Results: The seaweed of genus Laurencia demonstrated an overall low activity, with half maximal effective concentration (EC50) values >1.5 mg mL–1. Laurencia pacifica showed the best biocide effects with MIC of 6.25 μg mL–1 against Gram positive bacterial and cytotoxic potential with half inhibitory concentration (IC50) <30 μg mL–1 against Vero and HeLa cells. Conclusion: Some Laurencia species have a great antibacterial and cytotoxic activity which could be considered for future studies.
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How to cite this article:

Sara Garcia-Davis, Ivan Murillo-Alvarez, Mauricio Munoz-Ochoa, Edith Carranza-Torres, Ruth Garza-Padron, Eufemia Morales-Rubio and Ezequiel Viveros-Valdez, 2018. Bactericide, Antioxidant and Cytotoxic Activities from Marine Algae of Genus Laurencia Collected in Baja California Sur, Mexico. International Journal of Pharmacology, 14: 391-396.

DOI: 10.3923/ijp.2018.391.396

URL: https://scialert.net/abstract/?doi=ijp.2018.391.396

 
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