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International Journal of Pharmacology
  Year: 2018 | Volume: 14 | Issue: 3 | Page No.: 352-358
DOI: 10.3923/ijp.2018.352.358
Effect of Topical Treatment Versus Gavage Feeding of Ciprofloxacin on a Mouse Model of Acute Bacterial Rhinosinusitis
Wei Wang, Xiao-Dong Zhan , Tong Zhou, Xiao-Jing Wang, Hua-Long Qiang and Zhong-Qiang Cheng

Abstract:
Background and Objective: The sinonasal culture studies indicate acute bacterial rhinosinusitis (ABR), an inflammatory condition of nasal and paranasal cavity, characteristic after functional endoscopic sinus surgery. Antimicrobials have been widely used to treat ABR and subside the resultant inflammation. The present investigation compares responses of ciprofloxacin applied topically and by gavage feeding against ABR in mouse model of ABR. Methodology: Intranasal inoculation of Streptococcus pneumoniae was carried out in C57BL/6 mice for inducing ABR infection. One day after induction, ciprofloxacin administration was done topically and by gavage route in separate animal groups. Animal groups were sacrificed during the course of 5 days after inoculation and treatment. Inflammatory mediators and immunological cells (such as GR1, CD4, CD8 and CD11b cells) were quantified in sinus areas using flow cytometry. Bacterial population was determined by culturing nasal lavage from animals after specified periods. Two-tailed parametric t-test was used for calculation of significant values. Results: Ciprofloxacin gavage fed rats showed rapid depletion of microorganisms and of inflammation in contrast to topically treated animals. The reduction in the therapeutic effectiveness of topically applied ciprofloxacin could be due to sub-potent availability, quick nasal depletion or failure of drug suspension to approach the infected site. Conclusion: The study concluded that gavage treatment reduced the bacterial count more efficiently against topical treatment of ciprofloxacin in ABR mice animal models.
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How to cite this article:

Wei Wang, Xiao-Dong Zhan, Tong Zhou, Xiao-Jing Wang, Hua-Long Qiang and Zhong-Qiang Cheng, 2018. Effect of Topical Treatment Versus Gavage Feeding of Ciprofloxacin on a Mouse Model of Acute Bacterial Rhinosinusitis. International Journal of Pharmacology, 14: 352-358.

DOI: 10.3923/ijp.2018.352.358

URL: https://scialert.net/abstract/?doi=ijp.2018.352.358

 
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