• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. International Journal of Pharmacology
  2. Vol 14 (8), 2018
  3. 1051-1059
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

International Journal of Pharmacology

Year: 2018 | Volume: 14 | Issue: 8 | Page No.: 1051-1059
DOI: 10.3923/ijp.2018.1051.1059

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 274

Authors


Ghada  Hussein Naguib

Ghada Hussein Naguib

LiveDNA: 966.23507

Faten Ebraheem Al-Hazmi

Country: Saudi Arabia

Mallesh Kurakula

Country: Italy

Ayman Abdulaziz Al-dharrab

Country: Saudi Arabia

Khaled Mohamed Hosny

Country: Saudi Arabia

Hala Mohammed Alkhalidi

Country: Saudi Arabia

Mohamed Tharwat Hamed

Country: Saudi Arabia

Ali HabibAllah Hassan

Country: Saudi Arabia

Ameen M Al-mohammadi

Country: Saudi Arabia

Abeer Mohamed Alnowaiser

Country: Saudi Arabia

David Henry Pashley

Country: USA

Keywords


  • Zein
  • nanoparticles
  • antimicrobial
  • zinc oxide
  • dental aid
Research Article

Zein Coated Zinc Oxide Nanoparticles: Fabrication and Antimicrobial Evaluation as Dental Aid

Ghada Hussein Naguib Ghada  Hussein Naguib's LiveDNA, Faten Ebraheem Al-Hazmi, Mallesh Kurakula, Ayman Abdulaziz Al-dharrab, Khaled Mohamed Hosny, Hala Mohammed Alkhalidi, Mohamed Tharwat Hamed, Ali HabibAllah Hassan, Ameen M Al-mohammadi, Abeer Mohamed Alnowaiser and David Henry Pashley
Background and Objective: Bacterial strains resistance to conventional antibiotics has gained the attention of researchers to frame a materialistic approach and to identify an agent from physical source rather than biological. Zinc oxide (ZnO) has proven antimicrobial competence but had not explored as dental aid due to its solubility and agglomeration issues. This study aimed to utilize a newer technique to formulate ZnO nanoparticles and to refurbish with zein coating in order to optimize the desired pharmacological activity. Materials and Methods: Zein based ZnO nanoparticles were synthesized using hydrothermal technique at two different pH 1.24 and 11, respectively. Both zein coated and uncoated nanoparticles were characterized for particle size, surface charge, morphology, crystallinity and even metal oxide compatibility studies. In vitro dissolution studies were performed in order to determine the effect of zein over the solubility and release of ZnO nanoparticles. Antimicrobial assay for the zein coated ZnO nanoparticles were performed on Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis and Candida albicans using both Kirby-bauer and direct kill tests. Results: The uncoated ZnO nanoparticles were in 25 nm size but aggregate, tend to increase up to 280 nm after 1 h aqueous dispersion, oppositely zein coated were 40 nm with no aggregation. Scanning electron microscopy indicated agglomerate of uncoated ZnO nanoparticles while as distinct nanospheres when zein coated. Uncoated and zein coated nanoparticles exhibited a surface charge of 28 and -24 mV at pH 1.24 and -18 and -20 mV at pH 11, respectively. X-ray crystallography indicated crystalline nature and Fourier-transform infrared spectra with no possible interaction or formation of new product. Interestingly, at pH 1.4, zein coated ZnO nanoparticles release was just 20% at 12 h in comparison to uncoated indicating prolonged release. Conclusion: The synthesized zein coated ZnO nanoparticles were found to be highly crystalline with enhanced solubility and better compatibilities. Among the four microbial strains tested, zein coated ZnO nanoparticles exhibited higher pharmacological activity against C. albicans strains in comparison to the uncoated. These experimental outcomes can indicate the potential of ZnO nanoparticles in formulating an antimicrobial dental aid.
PDF Fulltext XML References Citation

How to cite this article

Ghada Hussein Naguib, Faten Ebraheem Al-Hazmi, Mallesh Kurakula, Ayman Abdulaziz Al-dharrab, Khaled Mohamed Hosny, Hala Mohammed Alkhalidi, Mohamed Tharwat Hamed, Ali HabibAllah Hassan, Ameen M Al-mohammadi, Abeer Mohamed Alnowaiser and David Henry Pashley, 2018. Zein Coated Zinc Oxide Nanoparticles: Fabrication and Antimicrobial Evaluation as Dental Aid. International Journal of Pharmacology, 14: 1051-1059.

DOI: 10.3923/ijp.2018.1051.1059

URL: https://scialert.net/abstract/?doi=ijp.2018.1051.1059

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved