Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Pharmacology
  Year: 2016 | Volume: 12 | Issue: 6 | Page No.: 669-674
DOI: 10.3923/ijp.2016.669.674
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Transdermal Local Anaesthetic Films of Tetracaine in Comparison to the Conventional Gel in Effective Management of Pain
Hong Lin, Yan Zhang, Ming Hou and Yue-lan Wang

Abstract:
Background: Tetracaine hydrochloride is a topical local anaesthetics used in the treatment of pain associated with minor surgical procedures it also gives relief from pain associated with various localized muscle, joint, post-herpetic neuralgia, arthritis and haemorrhoids. Objective: The present study is designed to prepare and evaluate transdermal patches of tetracaine hydrochloride to deliver drug for a longer period of time to circumvent severe pain after surgical procedures. Methodology: Transdermal patches of tetracaine hydrochloride were prepared by solvent casting method. The prepared patches were evaluated for the various evaluation parameters like thickness, surface pH, weight uniformity, content uniformity, folding endurance, swelling index, in vitro drug release study, in vitro test for mucoadhesion and in vivo studies. Results: All the formulations exhibited acceptable physical properties. In ex vivo drug diffusion study the patches exhibited controlled release upto 24 h. The formulation Th3 (containing EC, SCMC and PVP) showed the best performance in the ex vivo drug diffusion with 92.02±1.21% drug release after 24 h. In the clinical study on the patients suffering from the post operative pain it was observed that the Th3 decreased the pain score from 9.89±0.08 to 4.05±0.21 while the gel could decrease the same from 9.80±0.01 to 7.09±1.10 at the end of 24 h post application. Conclusion: It was concluded that the prepared transdermal patches of the tetracaine were having significant effect as compared to the tetracaine gel used conventionally.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Transdermal Drug Delivery System of Aceclofenac for Rheumatoid Arthritis and the Effect of Permeation Enhancers: In vitro and in vivo Characterization
How to cite this article:

Hong Lin, Yan Zhang, Ming Hou and Yue-lan Wang, 2016. Transdermal Local Anaesthetic Films of Tetracaine in Comparison to the Conventional Gel in Effective Management of Pain. International Journal of Pharmacology, 12: 669-674.

DOI: 10.3923/ijp.2016.669.674

URL: https://scialert.net/abstract/?doi=ijp.2016.669.674

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom