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International Journal of Pharmacology

Year: 2015 | Volume: 11 | Issue: 5 | Page No.: 513-517
Research Article

Evaluation of Antitumor Activity of Sodium Hypochlorite

Bahgat A. El-Fiky
Department of Animal Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt
Mohamed I. El-Naggar
Department of Forensic Medicine and Toxicology, Faculty of Medicine, Alexandria University, Egypt
Osama M. Badr
Department of Animal Biotechnology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt
The present study aimed to evaluate the antitumor activity of newly synthesized oxidized form of sodium hypochlorite. Different cell lines were susceptible to Sodium hypochlorite cytotoxicity at acute, LD50 and therapeutic doses of NaOCl. Therapeutic dose of sodium hypochlorite modulated the significantly reduced level of Hb, IL-12, TNF and the increased levels of creatinine, GPT and GOT towards the normal values. The histopathological study of liver, kidney and spleen groups showed a very significant improvement compared to normal and positive control groups. Sodium Hypochlorite exhibited an anticancer effect on different cell lines in vitro and against EAC in mice.
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