International Journal of Pharmacology

1811-7775 1812-5700

Asian Network for Scientific Information

10.3923/ijp.2015.513.517

El-Fiky

Bahgat A.

El-Naggar

Mohamed I.

M. Badr

Osama

5 2015

11 5 The present study aimed to evaluate the antitumor activity of newly synthesized oxidized form of sodium hypochlorite. Different cell lines were susceptible to Sodium hypochlorite cytotoxicity at acute, LD₅₀ and therapeutic doses of NaOCl. Therapeutic dose of sodium hypochlorite modulated the significantly reduced level of Hb, IL-12, TNF and the increased levels of creatinine, GPT and GOT towards the normal values. The histopathological study of liver, kidney and spleen groups showed a very significant improvement compared to normal and positive control groups. Sodium Hypochlorite exhibited an anticancer effect on different cell lines in vitro and against EAC in mice.

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Aggarwal, B. and J. Vilcek,

1992

ImmunolSer, 56 581 587 2

Bartels, H., M. Böhmer and C. Heierli,

1972

Clin. Chim. Acta, 37 193 197 3

Chiang, C.L., J.A. Ledermann, E. Aitkens, E. Benjamin, D.R. Katz and B.M. Chain,

2008

Clin. Cancer Res., 14 4898 4907 4

Colombo, N., T. van Gorp, G. Parma, F. Amant, G. Gatta, C. Sessa and I. Vergote,

2006

Crit. Rev. Oncol. Hematol., 60 159 179 5

Fiers, W.,

1991

in vivo level.]]>

FEBS Lett., 285 199 212 6

Freshney, R.I.,

2005

Culture of Animal Cells: A Manual of Basic Technique. 5th Edn., Pages: 695 Pages: 695 7

Trinchieri, G.,

2003

Nat. Rev. Immunol., 3 133 146 8

Gruss, H.J. and S.K. Dower,

1995

Blood, 85 3378 3404 9

Hamdullah, M.Z. Khan, A. Khan and I. Javed,

2010

Coturnix japonica).]]>

Hum. Exp. Toxicol., 29 779 788 10

Khanam, J.A., S.P. Bag, B. Sur and P. Sur,

1997

Ind. J. Pharmacol., 29 157 161 11

Mosmann, T. and R. Coffman,

1989

Annu. Rev. Immunol., 7 145 173 12

Osama, M.B.,

2013

Panax ginseng against acetaminophen-induced hepatotoxicity in mice.]]>

Egypt. J. Exp. Biol. (Zool.), 9 215 220 13

Portmann, B., I.C. Talbot, D.W. Day, A.R. Davidson, I.M. Murray-Lyon and R. Williams,

1975

J. Pathol., 117 169 181 14

Reitman, S. and S. Frankel,

1957

Am. J. Clin. Pathol., 28 56 63 15

Sadhu, U., M. Ghosh, S. Bhattacharya, S. Dutta, H. Das and U. Sanyal,

1994

Canc. Lett., 85 65 72 16

Steller, H.,

1995

Science, 267 1445 1449 17

Tiez, N.W.,

1976

Fundamentals of Clinical Chemistry. 18

Zhang, L., J.R. Conejo-Garcia, D. Katsaros, P.A. Gimotty and M. Massobrio et al.,

2003

New Engl. J. Med., 348 203 213