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International Journal of Pharmacology

Year: 2015 | Volume: 11 | Issue: 2 | Page No.: 106-113
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Authors

Gaurav Mahesh Doshi

Hemant Devidas Une

Keywords

Research Article

Screening of Polyalthia longifolia Leaves as Potential Immunomodulatory Target

Gaurav Mahesh Doshi and Hemant Devidas Une
Polyalthia longifolia Thwaites (Annonaceae) (PL) is a well known plant with major focus as antifungal and antibacterial agent. The present study highlights the immunomodulatory prospects of PL leaves with its prior identification of rutin in previous studies. Ethanolic extract at three dose levels (100, 250, 500 mg kg-1) was studied by Haemagglutination Antibody (HA) Titre and Delayed-Type Hypersensitivity (DTH) response using Sheep Red Blood Cells (SRBCs, 0.5×109) as antigens. Carbon Clearance (CC) test (Phagocytic Index) was estimated by Indian ink suspension. Complete Freud’s Adjuvant (CFA) induced arthritic model was studied with estimation of rat paw edema, body weights, arthritic index and biochemical parameters after acute toxicity studies. Acute toxicity results revealed that the extracts were found to be therapeutically safe upto 5000 mg kg-1. No significant immunoeffect was observed at 100 mg kg-1. Dose levels of 250 and 500 mg kg-1 showed significant immunostimmulation with HA Titre and DTH reaction (after 48 h). Phagocytic index (0.0143±0.001 and 0.0180±0.001) and CFA model showed decreased paw volume and knee joint erosion. Enhanced body weights and satisfactory biochemical results with increasing dose of the extract with arthritic index (1.29±0.13 and 1.19±0.11), respectively suggested satisfactory immunomodulatory prospective. Results were interpreted by One-way ANOVA followed by Dunnett test was used to undergo analysis. Polyalthia longifolia leaves could serve as a promising immunostimulator for treatment and prevention of immunodeficiency disorders in future.
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