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International Journal of Pharmacology

Year: 2012 | Volume: 8 | Issue: 7 | Page No.: 647-651
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Authors

Sadollah Mohammadi

Alireza Garjani

Moslem Najafi

Hossein Hamzeiy

Nasrin Maleki-Dizaji

Yadollah Omidi

Shabnam Fayezi

Masoud Darabi

Sara Mostafalou

Kambiz Hassanzadeh

Sajjad Khani

Keywords

Methylsulfonylmethane (MSM) is naturally accruing organic sulphur that is known as a potent anti-inflammatory compound. The aim of this study was to investigate the effect of MSM on mRNA expressions of angiotensinogen, endothelin-1 (ET-1) and Transforming Growth Factor (TGF)-β1 in rats with monocrotaline (MCT)-induced pulmonary arterial hypertension. Wistar rats were randomly assigned to 38-days pretreatment or 28-days treatment. MSM was administered to either 10 days before or 14 days after a single dose of MCT. Right Ventricle (RV) tissue samples were obtained to evaluate changes in the inflammatory genes expression using RT-PCR assay. The expression levels of angiotensinogen, ET-1 and TGF-β1 significantly were reduced (p<0.01) at efficient dose of MSM in MCT-induced pulmonary arterial hypertensive rats. Results suggest that harmful effects of MCT induced PAH on the RV function could be attenuated by anti-inflammatory actions through the suppression of local RAAS along with associated growth-promoting factors TGF-β1 and ET-1.
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How to cite this article

Sadollah Mohammadi, Alireza Garjani, Moslem Najafi, Hossein Hamzeiy, Nasrin Maleki-Dizaji, Yadollah Omidi, Shabnam Fayezi, Masoud Darabi, Sara Mostafalou, Kambiz Hassanzadeh and Sajjad Khani, 2012. Inhibitory Effects of Methylsulfonylmethane on Ventricular Hypertrophy Related Gene Expression. International Journal of Pharmacology, 8: 647-651.

DOI: 10.3923/ijp.2012.647.651

URL: https://scialert.net/abstract/?doi=ijp.2012.647.651

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