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International Journal of Pharmacology
  Year: 2011 | Volume: 7 | Issue: 4 | Page No.: 510-515
DOI: 10.3923/ijp.2011.510.515
 
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Protective Effect of Medicinal Garlic Against Isoprenaline Induced Myocardial Infarction in Rats

L. Vibha, S.M.B. Asdaq, S. Nagpal and R.K. Rawri

Abstract:
The present study was undertaken to evaluate the cardioprotective effect of medicinal garlic (MG) against isoprenaline (ISO) induced myocardial damage in rats. Sprague dawley male rats were orally given MG 250 and 500 mg kg-1 once daily for 3 weeks and losartan (LTN, 30 mg kg-1) for one week orally in their respective groups. Myocardial damage was induced by subcutaneous administration of isoprenaline (100 mg kg-1) for two consecutive days. A change in biomarkers and antioxidants levels reflects the influence of prophylactic treatment with MG. The lactate dehydrogenase (LDH) and creatine phosphokinase-MB (CK-MB) activities were fallen in serum and elevated in heart tissue of animals treated with low and high doses of MG as well as LTN compared to ISO control. Further, high and low doses of MG caused significant elevation in superoxide dismutase and catalase activities and reduction in thiobarbituric acid reactive species levels compared to ISO control. Hence it is concluded that medicinal garlic possesses potential to ameliorate the myocardial damage induced by isoprenaline in rats.
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