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International Journal of Pharmacology
  Year: 2008 | Volume: 4 | Issue: 4 | Page No.: 305-309
DOI: 10.3923/ijp.2008.305.309
Redeeming Measure of Atorvastatin in the Risk Factors of Cardiovascular Disease
Vijaya Anand, Chenniappan , Kalavathy , Uma , Saravanan and Sampath Kumar

Abstract:
The present study was designed to determine the effect of atorvastain on C-reactive protein (CRP) in patients with Cardiovascular diseases (CVD). One hundred and fifteen patients with or without CVD were recruited for the study, of which 75 belongs to control (untreated) and 40 were test group (treated) and received daily with 10 mg day-1 of atorvastatin. The patients were followed for over a period of 3 months. For entire study population, CRP along with lipid profile, SGOT and SGPT were measured 1st day and at the end of 3rd month of the treatment. There was greater reduction in the levels of both atherogenic lipoproteins and CRP were found in test group when compare with control. These findings suggest that statin-mediated anti-inflammatory effects may contribute to the ability of atorvastatin to reduce risk for CVD.
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