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International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 6 | Page No.: 475-481
DOI: 10.3923/ijp.2007.475.481
 
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The Antibiotic Potency of Amoxicillin-Clavulanate Co-Crystal

Ilma Nugrahani , Sukmadjaja Asyarie , Sundani Nurono Soewandhi and Slamet Ibrahim

Abstract:
The antibiotic activity related to compositions of amoxicillin-clavulanate co-crystals heated compare to the physical mixtures against non-betalactam bacteria: Sarcina lutea sp. has been studied. Amoxicillin trihydrate-potassium clavulanate were mixed in molar ratios: 0:10; 1:9; 2:8; until to 10:0 and heated at 50°C along 30 min. Inhibition diameters of the co-crystals were compared to amoxicillin heated and inhibition diameters of the physical mixtures were compared to amoxicillin raw material as counterparts. The results showed the tendency of increasing potency of the co-crystals in molar ratios 3:7-3:7 with significantly improvement at molar ratios 4:6; 6:4; 8:2 and 9:1 which proved different profile from the physical mixture.
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How to cite this article:

Ilma Nugrahani , Sukmadjaja Asyarie , Sundani Nurono Soewandhi and Slamet Ibrahim , 2007. The Antibiotic Potency of Amoxicillin-Clavulanate Co-Crystal . International Journal of Pharmacology, 3: 475-481.

DOI: 10.3923/ijp.2007.475.481

URL: https://scialert.net/abstract/?doi=ijp.2007.475.481

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