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International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 2 | Page No.: 195-197
DOI: 10.3923/ijp.2007.195.197
Phenoxybenzamine Treatment Is Insufficient to Prevent the Stress-induced Effects in Rat Gastrointestinal Tract
Maleki Hadi and Malekinejad Hassan

Abstract:
Phenoxybenzamine (POB) as an irreversible α-adrenoceptor antagonist was used to evaluate any possible therapeutic effects on stress-induced disorders in defecation in rats. In this study restriction stress was conducted on control and treated groups of rats with 0.1 and 1% of POB in a 2 mg kg-1 dose. After performing of restriction and drug administration, the frequency and weight of dropped faecal pellets were determined between 0-6, 6-12 and 12-24 h. The observed data showed no significant differences between control and treated animals (p>0.05). Present data suggest that although no significant differences have been observed in this trial but it could not be excluded due to other pharmacokinetic factors of phenoxybenzamine, which requires further studies to be conducted to elucidate more detail about it.
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How to cite this article:

Maleki Hadi and Malekinejad Hassan, 2007. Phenoxybenzamine Treatment Is Insufficient to Prevent the Stress-induced Effects in Rat Gastrointestinal Tract. International Journal of Pharmacology, 3: 195-197.

DOI: 10.3923/ijp.2007.195.197

URL: https://scialert.net/abstract/?doi=ijp.2007.195.197

 
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