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International Journal of Pharmacology
  Year: 2007 | Volume: 3 | Issue: 2 | Page No.: 179-182
DOI: 10.3923/ijp.2007.179.182
Comparison of Nitrofurantoin and Trimethoprim-Sulphamethoxazole for Long-Term Prophylaxis in Children with Recurrent Urinary Tract Infections
Behnaz Falakaflaki, Ramazan Fallah, Mohammad Reza Jamshidi, Farzaneh Moezi and Zohreh Torabi

Abstract:
The objective of this study was to compare prophylactic effect of nitrofurantoin and trimethoprim-sulphamethoxazole (TMP-SMX) in recurrent Urinary Tract Infections (UTI) in children and to determine antibiotic resistance pattern while receiving prophylaxis. One hundred and thirty two patients in two similar groups were randomized to receive either TMP-SMX (n = 66) or nitrofurantoin (n = 66) as single night dose for 6 months. Age, sex, indication for prophylaxis, occurrence of UTI, culture and sensitivity results were recorded. Patients were categorized into three age groups: 3-12 months, 1-5 years, 6-12 years. Nitrofurantoin was more effective than TMP-SMX in preventing recurrent UTI. Recurrence rate was 36.2% in nitrofurantoin group compared with 63.8% in the TMP-SMX group (p = 0.029). This protective effect was more significant in children aged 1-5 years compared to other age groups (p = 0.046). In nitrofurantoin group, 37.5% of the organisms causing the UTIs were resistant to drug. In TMP-SMX group, 56% of the organisms were resistant to the prophylactic agent. Nitrofurantoin has a lower rate of recurrence and causes less emergence of resistance bacteria than TMP-SMX, therefore is more suitable for prevention of recurrent UTI in children.
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How to cite this article:

Behnaz Falakaflaki, Ramazan Fallah, Mohammad Reza Jamshidi, Farzaneh Moezi and Zohreh Torabi, 2007. Comparison of Nitrofurantoin and Trimethoprim-Sulphamethoxazole for Long-Term Prophylaxis in Children with Recurrent Urinary Tract Infections. International Journal of Pharmacology, 3: 179-182.

DOI: 10.3923/ijp.2007.179.182

URL: https://scialert.net/abstract/?doi=ijp.2007.179.182

 
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