Research Article

Repeatedly Heated Frying Oil and High Cholesterol Diet are Detrimental to the Bone Structure of Ovariectomised Rats

A.S. Nazrun, C.M. Chew, M. Norazlina, J. Kamsiah and Ima S. Nirwana

Oxidative stress and hypercholesterolemia have been shown to contribute to post-menopausal osteoporosis. In post-menopausal women, the use of repeatedly heated frying oils may aggravate oxidative stress condition while intake of high cholesterol diet may worsen hypercholesterolaemia. The aim of this study is to determine the combined effects of repeatedly heated (five times) frying oils (palm or soy oil) and high cholesterol diet on the bone structure of ovariectomised rats, an animal model of post-menopausal osteoporosis, by using bone histomorphometry. It was found that the addition of fresh or once-heated palm or soy oil into high cholesterol diet was able to protect ovariectomised rats bone from structural deterioration. However, when these oils were repeatedly heated, the protective effects were lost and the bone structures of the ovariectomised rats were either maintained by palm oil or worsen by soy oil.

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A.S. Nazrun, C.M. Chew, M. Norazlina, J. Kamsiah and Ima S. Nirwana, 2007. Repeatedly Heated Frying Oil and High Cholesterol Diet are Detrimental to the Bone Structure of Ovariectomised Rats. International Journal of Pharmacology, 3: 160-164.

DOI: 10.3923/ijp.2007.160.164

URL: https://scialert.net/abstract/?doi=ijp.2007.160.164

International Journal of Pharmacology

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Authors

A.S. Nazrun

C.M. Chew

M. Norazlina

J. Kamsiah

Ima S. Nirwana

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Research Article

Repeatedly Heated Frying Oil and High Cholesterol Diet are Detrimental to the Bone Structure of Ovariectomised Rats

How to cite this article

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