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International Journal of Pharmacology

Year: 2006 | Volume: 2 | Issue: 6 | Page No.: 601-607
Research Article

Antidiabetic and Hypolipidemic Effect of Cassia auriculata in Alloxan Induced Diabetic Rats

P. Uma Devi
Department of Biochemistry, Institute for Laboratory Medicines, KMCH, Coimbatore, India
S. Selvi
Department of Biochemistry, Institute for Laboratory Medicines, KMCH, Coimbatore, India
S. Suja
Department of Biochemistry, Institute for Laboratory Medicines, KMCH, Coimbatore, India
K. Selvam
Department of Biotechnology, Institute for Laboratory Medicines, KMCH, Coimbatore, India
P. Chinnaswamy
Dr. NGP Arts and Science College, C01mbatore, India Director, Institute for Laboratory Medicines, KMCH, Coimbatore, India
Several reports have shown the various effects of Cassia auriculata flower extract such as hypoglycemic, hypolipidemic, antioxidant and hypotensive effects. The present study was conducted to investigate the antidiabetic and hypolipidemic efficacy of various parts (root, stem, leaves and flowers) of Cassia auriculata on alloxan-induced diabetic rats. In the in vivo experiments, alloxan induced diabetic wistar strains of male albino rats were randomized into 7 groups. It includes 1) Control 2) Diabetic control. 3) Diabetic +250 mg kg-1 b.w. of CA root extract 4) Diabetic+250 mg kg-1 b.w. of CA stem extract 5) Diabetic+250 mg kg-1 b.w. of CA leaf extract 6) Diabetic +250 mg kg-1 b.w. of CA flower extract 7). Diabetic+100 mg kg-1 Tolbutamide. The groups were treated with the plant extracts and drug along with a control for a period of 28 days. Serum and plasma from the experimented animals were collected and assayed for glucose tolerance (acute and chronic study), insulin, triglycerides and cholesterol. Results showed that there is a significant level of reduction in the serum glucose and triglycerides and cholesterol and increase in the plasma insulin levels for the flower and leave extracts of Cassia auriculata when compared to root and stem extracts. From this study, it is confirmed that the leaves and flowers of Cassia auriculata has anti diabetic and anti lipidemic effect and these could be used in diabetic and CHD (Coronary Heart Disease) management.
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