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International Journal of Pharmacology
  Year: 2006 | Volume: 2 | Issue: 3 | Page No.: 303-308
DOI: 10.3923/ijp.2006.303.308
Anti-inflammatory Activity and Mechanism of Action of Vitex negundo Linn
Vishal Ramprakash Tandon and Rajesh Kumar Gupta

Abstract:
To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced hind paw edema and cotton pellet granuloma test in albino rats were employed to study the anti-inflammatory activity of Vitex negundo (VN) leaf extract. The mechanism of anti-inflammatory action was explored by observing its effect on oxytocin induced contractions in rat uterus and oxidative stress. VN extract was administered orally in graded doses (100, 250 and 500 mg kg-1) as single dose therapy and twice daily for 7 day in respective inflammatory experimental models. The effects were compared with phenylbutazone (100 mg kg-1) orally in carrageenin induced hind paw edema method and ibuprofen (200 mg kg-1.B.DX 7 days) orally in cotton pellet granuloma test as standard controls, respectively. The test drug showed significant anti-inflammatory activity in dose dependant manner in both experimental models. VN inhibited oxytocin induced contractions of rat uterus and plasma MDA (malondialdehyde) levels significantly. These observations suggest that VN possesses anti-inflammatory activity against acute as well as sub-acute inflammation, which appear to be due to prostaglandin inhibition and reduction of oxidative stress respectively, which needs to be substantiated by further study.
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How to cite this article:

Vishal Ramprakash Tandon and Rajesh Kumar Gupta , 2006. Anti-inflammatory Activity and Mechanism of Action of Vitex negundo Linn. International Journal of Pharmacology, 2: 303-308.

DOI: 10.3923/ijp.2006.303.308

URL: https://scialert.net/abstract/?doi=ijp.2006.303.308

 
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