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International Journal of Pharmacology

Year: 2005 | Volume: 1 | Issue: 3 | Page No.: 277-280
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Authors

M.N. Somchit

M.H.N. Shukriyah

A.A. Bustamam

A. Zuraini

Keywords

Research Article

Anti-pyretic and Analgesic Activity of Zingiber zerumbet

M.N. Somchit, M.H.N. Shukriyah, A.A. Bustamam and A. Zuraini
The objective of the present study was to evaluate the anti-pyretic and analgesic activities of aqueous and ethanol extracts of Zingiber zerumbet rhizomes. The anti-pyretic activity of Zingiber zerumbet (25, 50 and 100 mg kg-1) was studied in Brewer`s yeast-induced pyrexia in rats. The analgesic activity of Zingiber zerumbet (10, 25, 50 and 100 mg kg-1) was studied using acetic acid-induced writhing in mice. Both aqueous and ethanol extracts of Zingiber zerumbet showed significant anti-pyretic activities in Brewer`s yeast-induced pyrexia in rats throughout the observation period of 8 h. The ethanol extract of the rhizomes of Zingiber zerumbet however significantly decreased the writhing movements in mice in acetic acid-induced writhing test. In conclusion, rhizomes Zingiber zerumbet have both analgesic and anti-pyretic activities.
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