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International Journal of Osteoporosis and Metabolic Disorders
  Year: 2017 | Volume: 10 | Issue: 1 | Page No.: 1-9
DOI: 10.3923/ijom.2017.1.9
 
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Low Dose Marantodes pumilum Leaf and Roots Extracts Preserved Bone Structure in Ovariectomized Rats

Tijjani Rabiu Giaze, Ahmad Nazrun Shuid , Ima Nirwana Soelaiman, Norliza Muhammad and Norazlina Mohamed

Abstract:
Background: Marantodes pumilum var. alata, a phytoestrogen-rich herb, has been reported to exert protection on bone of estrogen-deficient animals against osteoporosis. However, comparative osteo-protective activity of its leaf and root extracts has not been fully elucidated. Objective: The aim of this study was to investigate and compare the osteo-protective effects of aqueous leaf and root extracts of Marantodes pumilum var alata in ovariectomized rat model. Methodology: Twenty-seven female rats were divided into nine groups: sham-operated (Sham); ovariectomized control (OVXC); 64.5 μg kg–1 day–1 estrogen treatment (ERT); 20 mg kg–1 day–1 (MPv20), 50 mg kg–1 day–1 (MPv50) and 100 mg kg–1 day–1 (MPv100) doses leaf extract treatments and; 20 mg kg–1 day–1 (MPr20), 50 mg kg–1 day–1 (MPr50) and 100 mg kg–1 day–1 (MPr100) doses root extract treatment groups. After 8 weeks treatment period, the left femora were excised and investigated using Micro-computed tomography (μ-CT). Results were analysed using one-way ANOVA and Tukey's post hoc test. Results: The MPv20, MPv50 and MPr20 groups showed significantly higher (p<0.05) bone mineral density on the trabecular bone while all treatment groups recorded significantly higher (p<0.05) tissue mineral density on the cortical bone when compared with OVXC group. Trabecular bone number and separation were significantly higher and lower (p<0.05), respectively, in both MPv20 and MPr20 groups. Significantly higher (p<0.05) cortical bone area fraction and thickness in MPv20 group and medullary area in MPr20 group were observed. Conclusion: Lower dose (20 mg kg–1 day–1) of both leaf and root extracts of Marantodes pumilum var alata preserved bone mineral density and micro-architecture of estrogen-deficient rats better than higher doses.
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How to cite this article:

Tijjani Rabiu Giaze, Ahmad Nazrun Shuid, Ima Nirwana Soelaiman, Norliza Muhammad and Norazlina Mohamed, 2017. Low Dose Marantodes pumilum Leaf and Roots Extracts Preserved Bone Structure in Ovariectomized Rats. International Journal of Osteoporosis and Metabolic Disorders, 10: 1-9.

DOI: 10.3923/ijom.2017.1.9

URL: https://scialert.net/abstract/?doi=ijom.2017.1.9

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