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International Journal of Cancer Research
  Year: 2010 | Volume: 6 | Issue: 4 | Page No.: 234-242
DOI: 10.3923/ijcr.2010.234.242
Feeding Almonds and Pecans Reduced Development of Azoxymethane Induced Precancerous Lesions
A.A. Miller, M. Verghese, J. Boateng, L. Shackelford and L.T. Walker

Abstract:
The aim of the study was to test the chemopreventive potential of almonds and pecans on (AOM) induced aberrant crypt foci (ACF). Following a 1 week period of acclimatization, 30 Fisher 344 male rats were randomly divided into 5 groups. One group was fed AIN93G (growth) diet as Control(C) and the other groups were fed almonds (A) and pecans (P) at 5% (5 g/100 g level) and 10% (10 g/100 g level). At 7 and 8 weeks of age rats received subcutaneous injections of Azoxymethane (AOM) at 16 mg kg-1 body weight and were killed by CO2 asphyxiation at 17 weeks of age. Selected enzyme activities such as, glutathione-s-transferase (GST), catalase (CAT) and superoxide dismutase (SOD) were determined. ACF incidence in rats fed Pecans and Almonds at 5 and 10% dose levels were significantly (p<0.05) lower than rats fed control. ACF was reduced by 46-61% in the treatment groups compared to the control. GST and CAT activities (μmol g-1) in rats fed Pecan and Almonds at 5 and 10% dose levels were significantly higher (p<0.05) compared to control fed rats and ranged from 22.03 to 26.44 and 2.38 to 2.98, respectively. We also noted a significant increase in SOD activity (μmol g-1) in rats fed the treatment diets compared to those fed control. Present data indicate that feeding almonds and pecans significantly (p<0.05) reduced incidence of AOM induced ACF which are precancerous lesions.
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How to cite this article:

A.A. Miller, M. Verghese, J. Boateng, L. Shackelford and L.T. Walker, 2010. Feeding Almonds and Pecans Reduced Development of Azoxymethane Induced Precancerous Lesions. International Journal of Cancer Research, 6: 234-242.

DOI: 10.3923/ijcr.2010.234.242

URL: https://scialert.net/abstract/?doi=ijcr.2010.234.242

 
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