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International Journal of Cancer Research
  Year: 2008 | Volume: 4 | Issue: 4 | Page No.: 146-153
DOI: 10.3923/ijcr.2008.146.153
 
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Inhibitory Effects of Feeding Selected Levels of Peanuts on Azoxymethane-Induced Aberrant Crypt Foci in Male Fisher 344 Rats

M. Guyton, M. Verghese, L. T. Walker, C. B. Chawan, L. Shackelford, J. Jones and J. Khatiwada

Abstract:
The aim of this study was to explicate the effect of feeding peanuts at 3 levels (10, 15 and 20 g 100-1 g of feed) on azoxymethane (AOM)-induced Aberrant Crypt Foci (ACF) in Fisher 344 male rats. Four groups of rats were fed AIN93-G control diet (n = 8) and 3 experimental diets containing 10, 15 and 20% peanuts (n = 8) for 13 weeks. All rats received 16 mg kg-1 body weight of AOM at 7 and 8 week of age. The rats continued to receive the assigned diets until euthanized by CO2 at 17 weeks of age. The percent reductions in ACF in the groups consuming diets containing 10, 15 and 20% peanuts were 31.9, 48.7 and 61%, respectively. GST activity (μmol mg-1) in the rats fed control diet was significantly (p<0.05) lower compared to the rats fed peanuts. Present results indicate that feeding peanuts significantly reduced AOM-induced ACF in Fisher 344 male rats. The phytochemicals present in peanuts may have antitumor properties and could possibly reduce colon cancer.
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How to cite this article:

M. Guyton, M. Verghese, L. T. Walker, C. B. Chawan, L. Shackelford, J. Jones and J. Khatiwada, 2008. Inhibitory Effects of Feeding Selected Levels of Peanuts on Azoxymethane-Induced Aberrant Crypt Foci in Male Fisher 344 Rats. International Journal of Cancer Research, 4: 146-153.

DOI: 10.3923/ijcr.2008.146.153

URL: https://scialert.net/abstract/?doi=ijcr.2008.146.153

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