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Current Research in Neuroscience

Year: 2016 | Volume: 6 | Issue: 1 | Page No.: 16-22
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Authors

Souravh Bais

Souravh Bais

Naveena Abrol

Keywords

Review Article

Review on Chemistry and Pharmacological Potential of Amentoflavone

Souravh Bais Souravh Bais's LiveDNA and Naveena Abrol
Amentoflavone is a polyphenolic compound present in various plants including Ginkgo biloba, Chamaecyparis obtusa (hinoki), Hypericum perforatum (St. John’s Wort) and Xerophyta plicata. It mainly shows its antagonist activity at κ-opioid receptor and at the allosteric benzodiazepine site of the GABA (A) receptor as a negative allosteric modulator. Its boiling point is 910.00-911.00°C at 760.00 mmHg (est) and melting point is more than 572°F. It occurs in solid state and weight is 538.46. Its chemical formula is C3OH18O10 and molar mass is 538.45 g moL–1. Amentoflavone is analytically observed by various spectroscopical parameters i.e., HPLC, TLC, paper chromatography. Structural determination can be done by UV, NMR and IR parameters. Amentoflavone shows various molecular mechanisms i.e., phosphodiesterase inhibition, muscular strength, acetylcholinesterase inhibition, inhibition of PTP1B, weak vasodilation and also inhibit fatty acid synthesis.
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