Current Research in Neuroscience1996-3408xxxx-xxxxAcademic Journals Inc.10.3923/crn.2016.16.22BaisSouravh AbrolNaveena 1201661Amentoflavone is a polyphenolic compound present in various plants including Ginkgo biloba, Chamaecyparis obtusa (hinoki), Hypericum perforatum (St. Johns Wort) and Xerophyta plicata. It mainly shows its antagonist activity at κ-opioid receptor and at the allosteric benzodiazepine site of the GABA (A) receptor as a negative allosteric modulator. Its boiling point is 910.00-911.00°C at 760.00 mmHg (est) and melting point is more than 572°F. It occurs in solid state and weight is 538.46. Its chemical formula is C3OH18O10 and molar mass is 538.45 g moL1. Amentoflavone is analytically observed by various spectroscopical parameters i.e., HPLC, TLC, paper chromatography. Structural determination can be done by UV, NMR and IR parameters. 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