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Asian Journal of Biochemistry
  Year: 2008 | Volume: 3 | Issue: 5 | Page No.: 330-336
DOI: 10.3923/ajb.2008.330.336
 
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Rationalization of Physicochemical Property of Some Substituted Benzimidazole Bearing Acidic Heterocyclic Towards Angiotensin II Antagonist: A QSAR Approach

Anurekha Jain and S.C. Chaturvedi

Abstract:
Various lead structures of the compounds of angiotensin II antagonist are reported in the literature. Studying the Structure-Activity Relationships (SAR) for such compounds has been a fascination for scientists and efforts have been made to identify the essential physico-chemical requirements for the angiotensin type 1 (AT1) receptor selective, angiotensin type 2 (AT2) receptor selective and some AT1 and AT2 balanced antagonistic activity compounds. With an aim to identify the structural requirements for selective AT1 activity, a Quantitative SAR (QSAR) analysis was carried out on a series of benzimidazole derivative bearing acidic heterocycle AII receptor antagonists. The QSAR expressions were generated using 19 compounds and the predictive ability of the resulting model was evaluated against a test set of 7 compounds. The internal (cross validated squared correlation coefficient) and external consistency (predictive correlation coefficient) of the QSAR model was 0.895 and 0.405, respectively. Analysis of result from the present QSAR study indicates that geometrical, structural and shape descriptors govern the angiotensin II AT1 inhibitory activity.
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How to cite this article:

Anurekha Jain and S.C. Chaturvedi, 2008. Rationalization of Physicochemical Property of Some Substituted Benzimidazole Bearing Acidic Heterocyclic Towards Angiotensin II Antagonist: A QSAR Approach. Asian Journal of Biochemistry, 3: 330-336.

DOI: 10.3923/ajb.2008.330.336

URL: https://scialert.net/abstract/?doi=ajb.2008.330.336

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