Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Asian Journal of Biochemistry
  Year: 2006 | Volume: 1 | Issue: 1 | Page No.: 1-17
DOI: 10.3923/ajb.2006.1.17
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Nitric Oxide: Role in Biological System
P.D. Lokhande , B.S. Kuchekar , A.R. Chabukswar and S.C. Jagdale

Abstract:
Nitric oxide is synthesized by the enzyme nitric oxide synthase. Nitric oxide synthase maintains the normal levels of nitric oxide in body. Discovery of nitric oxide synthase has lead to a new era in the drug research. Nitric oxide regulates the normal physiological balance and functions of the body. Three isoforms of nitric oxide synthase have been identified, an endothelial type, a neuronal type and a macrophage (inducible) type. Nitric oxide helps in regularizing normal blood pressure, relaxation of smooth muscle, release of growth hormone, insulin and pancreatic polypeptide. Nitric oxide plays very important role in host defense mechanism of body. Studies have shown that excess or deficiency of nitric oxideis associated with many diseases. In spite of the involvement of NO in several physiological functions, overproduction of NO can be harmful. An excess of NO produced by nNOS or iNOS is involved in pathological conditions, including post-ischemic stroke damage, septic shock, seizures, schizophrenia, migraine headaches, Alzheimer`s disease, development of colitis, tissue damage and inflammation, osteoporosis and rheumatoid arthritis, depression, neuroimmune diseases. In this study we have taken review of the important role of nitric oxide in biological system and the strategies to inhibit the overproduction of nitric oxide.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Effect of L-Arginine on Some Biochemical Markers of Metabolic Syndrome Associated with Brain Function in Female Wistar Rats
  •    Effect of L-arginine on Some Anthropometric Parameters of Metabolic Syndrome in Normal Female Wistar Rats
  •    Influence of L-arginine on the Heart Histology and Function Markers of Metabolic Syndrome in Female Wistar Albino Rats
  •    Alterations in the Liver Histology and Markers of Metabolic Syndrome Associated with Inflammation and Liver Damage in L-arginine Exposed Female Wistar Albino Rats
How to cite this article:

P.D. Lokhande , B.S. Kuchekar , A.R. Chabukswar and S.C. Jagdale , 2006. Nitric Oxide: Role in Biological System. Asian Journal of Biochemistry, 1: 1-17.

DOI: 10.3923/ajb.2006.1.17

URL: https://scialert.net/abstract/?doi=ajb.2006.1.17

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 

       

       

Curve Bottom