Hassan Rakhshandeh
Pharmacological Research Center of Medicinal Plants, Ghaem Medical Center, Mashad University of Medical Sciences, Mashad, Iran
Nasser Vahdati-Mashhadian
3Department of Pharmacodynamics and Toxicology, School of Pharmacy,
Mashad University of Medical Sciences, Mashad, Iran
Karim Dolati
Pharmacological Research Center of Medicinal Plants, Ghaem Medical Center, Mashad University of Medical Sciences, Mashad, Iran
Mahmoud Hosseini
Department of Physiology, Ghaem Medical Center, Mashad University of Medical Sciences, Mashad, Iran
ABSTRACT
In this study, analgesic effects of the aqueous, ethanolic and chloroformic extracts of this plant were investigated. Mice were treated with IP injection of 100, 500 and 1000 mg kg-1 aqueous, ethanolic and chloroformic extracts of the plant and analgesic effects were assessed using hot plate and tail flick methods. The results showed that ethanolic extract had significant analgesic effect comparable to morphine. As, pretreatment of animals with naloxone significantly reduced analgesic effect of the extract, the analgesic effect of ethanolic extract seems to be at least, in part through opioid system. No analgesic effects have been observed with aqueous or chloroformic extracts of the plant.
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How to cite this article
Hassan Rakhshandeh, Nasser Vahdati-Mashhadian, Karim Dolati and Mahmoud Hosseini, 2008. Antinociceptive Effect of Rosa damascena in Mice. Journal of Biological Sciences, 8: 176-180.
DOI: 10.3923/jbs.2008.176.180
URL: https://scialert.net/abstract/?doi=jbs.2008.176.180
DOI: 10.3923/jbs.2008.176.180
URL: https://scialert.net/abstract/?doi=jbs.2008.176.180
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