E. U. Etuk
Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto
P. A. Onyeyili
Department of Veterinary Physiology and Pharmacology, University of Maiduguri, Nigeria
B. Y. Muhammed
Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University, Sokoto
ABSTRACT
Pharmacokinetics studies were performed in healthy red Sokoto goats using chloramphenicol 25 mg kg-1. Following the drug administration intravenously and intramuscularly samples of plasma were obtained in the goats at various time intervals. Measurable blood levels of the drug were obtained in goats for 6 h after intravenous injection and for 9 h after intramuscular administration. A mean plasma concentration of chloramphenicol (25.63±2.01 μg mL-1) was obtained at 0.08 h (5 min) after the intravenous administration of the drug while the peak plasma concentration of the drug following intramuscular treatment was 9.64±0.74 μg mL-1 after 0.25 h (30 min). The apparent volume of distribution and the total body clearance of chloramphenicol from the Sokoto red goats were higher after intramuscular than intravenous administration. About 80% of the drug administered intramuscularly reached the plasma. This result has yielded baseline data for further investigation(s) of the drug.
PDF References
How to cite this article
E. U. Etuk, P. A. Onyeyili and B. Y. Muhammed, 2005. Pharmacokinetics of Chloramphenicol Following Intravenous and Intramuscular Administration of the Drug to Healthy Sokoto Red Goats. International Journal of Pharmacology, 1: 239-243.
DOI: 10.3923/ijp.2005.239.243
URL: https://scialert.net/abstract/?doi=ijp.2005.239.243
DOI: 10.3923/ijp.2005.239.243
URL: https://scialert.net/abstract/?doi=ijp.2005.239.243
REFERENCES
- English, P.B. and A.A. Seawright, 1961. Plasma and tissue concentrations of chloramphenicol in the pig. Aust. Vet. 37: 9-13.
CrossRefDirect Link - Hughes, D.W. and L.K. Diamond, 1964. Chloramphenicol in blood, simple chemical estimations in patients receiving multiple antibiotics. Antibiot. Sci., 114: 296-297.
CrossRefDirect Link - Burrows, G.E., P.B. Barto and B.R. Weeks, 1986. Chloramphenicol, lincomycin and oxytetracycline disposition in calves with experimental pneumonic pasteurellosis. J. Vet. Pharmacol. Therapeut., 9: 213-222.
CrossRefDirect Link