S. B.Olaleye
Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria
Y. Raji
Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria
S. A. Onasanwo
Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria
P. Erigbali
Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria
S.O. Oyesola
Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria
A. Odukanmi
Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria
I.O. Omotosho
Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria
R.A. Elegbe
Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria
ABSTRACT
In the present study, the effects of long-term, low level (Lo-Pb) and high level (Hi-Pb) exposure of rats to lead on total gastric juice secretion and experimental ulceration were studied. Rats were exposed to low (0.01%; 100 ppm) or high (0.5%, 5,000 ppm, HiPb) levels of lead for a period of 15 weeks. The formation of ulcers was induced by hypothermic stress, the administration of indomethacin and the application of an HCl/Ethanol mixture. Exposure of animals to lead significantly increased gastric lesions produced by HCl/Ethanol mixture and indomethacin but not those induced by restraint stress. Both the LoPb and HiPb treatments significantly increased gastric acidity and reduced gastric juice volume. The results underscore the role of cumulative lead exposure in the aetiology of gastric ulcers in high lead areas.
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How to cite this article
S. B.Olaleye, Y. Raji, S. A. Onasanwo, P. Erigbali, S.O. Oyesola, A. Odukanmi, I.O. Omotosho and R.A. Elegbe, 2006. Potentiation of Gastric Ulceration by Experimental Lead Exposure in Rats. Journal of Biological Sciences, 6: 480-484.
DOI: 10.3923/jbs.2006.480.484
URL: https://scialert.net/abstract/?doi=jbs.2006.480.484
DOI: 10.3923/jbs.2006.480.484
URL: https://scialert.net/abstract/?doi=jbs.2006.480.484
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