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Review Article
 

Plants for Female Fertility Regulation: A Review



A.S. Ansari, K. Sevliya, I. Mohammad, A. Badar and N.K. Lohiya
 
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ABSTRACT

The review provides updated scientific information of medicinal plants with proven female anti-fertility activity. The objective is to highlight the fertility regulating agents from plant origin for females. This review is a result of conduction of a literature search from different sources viz., the library of our institution, pubmed, google search and other personal sources. A total of 317 references were found using 204 plants for fertility regulation in females for the period of 68 years (1947-2015). The biological name, plant part, type of extract, dose, mode of administration, animal model and pharmacological action of these plants have been reviewed in this study to explore some of the ways in which phytotherapy may contribute and focus on research into potential herbal tools for population control.

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A.S. Ansari, K. Sevliya, I. Mohammad, A. Badar and N.K. Lohiya, 2017. Plants for Female Fertility Regulation: A Review. Journal of Pharmacology and Toxicology, 12: 57-75.

DOI: 10.3923/jpt.2017.57.75

URL: https://scialert.net/abstract/?doi=jpt.2017.57.75
 
Received: November 21, 2016; Accepted: February 06, 2017; Published: March 15, 2017



INTRODUCTION

Global population has severely disturbed the ecological balance and has forced mankind to develop new fertility regulating techniques. Although, considerable progress has been made in the field of chemically formulated contraceptive methods but many of them have adverse effects. Therefore, it is necessary to screen biologically active fertility regulating agents which are safe. Plants have been used worldwide for screening of various human ailments since ancient times. About 325 extracts from 75 plants with anti-fertility actions were screened by Garg et al.1. Kulshreshtha and Srivastava2 recognized anti-fertility action in 43 folkloric traditional plants. The Task Force on Plants for Fertility Regulation set up by the World Health Organization (WHO) identified approximately 30 plants with anti-implantational activities but none of these have reached the stage of clinical examination3. Hence, the detailed information including plants scientific name, part, extract, dose, administration mode, animal model and pharmacological action have been reviewed in this study (Table 1).

The status of the plant products which have undergone clinical trials and have shown promising results is briefly reviewed.

Pippaliyadi vati: It has been used in combination of powdered fruit berries of Embelia ribes, Piper longum and borax, as an ayurvedic contraceptive, since ancient times. Phase I clinical trials have been completed at the Postgraduate Institute of Medical Education and Research, Chandigarh, the JIPMER, Pondicherry and at the KEM Hospital, Mumbai. The trial was preceded in Central Council for Research in Ayurveda and Sidha, Kolkata and Hyderabad and acute, subacute toxicology and teratological examination carried out at the National Institute of Immunology, New Delhi3. The researchers concluded that in utero exposure to pippaliyadi did not exhibit any adverse effects on postnatal development and reproductive performance of the F1 progeny4.

Consap: Saponins (obtained from Sapindus mukorossi) have spermicidal activity. Saponins caused alterations in the glycoproteins associated with the lipid bilayer of plasma membrane of spermatozoa, observed under scanning electron microscope5. Plant extracts altered biochemical and biophysical changes in the sperm membrane during sperm maturation without changing the testicular and epididymal morphology6. A contraceptive cream known as consap was developed under CDRI’s contraceptive development programme. It has passed through phase I, II and III clinical trials and proved to be an effective fertility regulating agent. Hindustan Latex Limited, Mumbai licensed the cream to market as non-hormonal herbal spermicidal contraceptive7.

Praneem: Praneem, combination of seed extract of Azadirachta indica, fruit extract of Sapindus mukorossi and Mentha citrata oil has emerged as an intravaginal polyherbal (PPH) cream and pessary at the National Institute of Immunology, Delhi, India. The formulation was safe under sub-acute toxicity studies in monkeys and has effective contraceptive efficacy in rabbits and monkeys after intravaginal application8. This has undergone phase II clinical trials9 and was accepted by the study participants in a phase II safety and acceptability study done in Pune, India10,11. Clinical trials were carried out in 3 centres in India, viz., Postgraduate Institute of Medical Education and Research, Chandigarh; Safdarjang Hospital, New Delhi and Kamla Nehru Memorial Hospital, Allahabad. No toxic effects were observed on intravaginal use during clinical investigations12. A microbicide praneem polyherbal tablet has successfully passed through phase III clinical trials and licensed to M/s Panacea Biotec.

Carica papaya: As a male contraceptive, a series of experiments have been conducted by Lohiya and associates with various extracts, fractions and sub-fractions with varying dose and duration in male rats, rabbits and langur monkeys. The chloroform extract exerted maximum antifertility activity in rats and rabbits, mainly due to its mild estrogenic property. The benzene chromatographic fraction of chloroform extract produced inhibition of cauda epididymal sperm motility in rats with reduced sperm density and morphological changes of the spermatozoa and azoospermia in rabbits. The methanol and ethyl acetate sub-fractions obtained from the benzene chromatographic fraction also showed motility inhibition properties in rats following 30-60 days of treatment and azoospermia in rabbits within 15 days of treatment13,14.

Apart from effective male contraceptive, it has been equally screened as a fertility regulating agent in females. Carica papaya seeds and fruits exerted abortion in women15. In countries like Indonesia, Malaysia and Myanmar papaya have been used indigenously as abortifacients16-18. About 82% of females avoided papaya consumption during pregnancy in Tamil Nadu, India19.

Extensive toxicological investigations have also been carried out with Methanol Sub Fraction (MSF) of the benzene chromatographic fraction of the chloroform extract of papaya seeds following a single high dose administration or daily administration upto 10 times of contraceptive dose for a period of 28 and 90 days and long-term daily administration upto 10 times for a period of 52 weeks and 2 years in rats indicated no associated health hazards.

Table 1: Summary of plants with reported anti-fertility activity in female
Image for - Plants for Female Fertility Regulation: A Review
Image for - Plants for Female Fertility Regulation: A Review
Image for - Plants for Female Fertility Regulation: A Review
Image for - Plants for Female Fertility Regulation: A Review
Image for - Plants for Female Fertility Regulation: A Review
Image for - Plants for Female Fertility Regulation: A Review
a1: Alcoholic extract, a2: Alcoholic extract (arjunalone), a3: Aqueous extract, a4: Abridin, a5: Aristolic acid, a6: Alkaloid, a7: Alkaloid (aroborinine), a8: Alkaloid (binsindole), a9: Alkaloid (vasicine), a10: Acetone, b1: Benzene extract, b2: n-butanol extract, b3: Butanol fraction, c1: Chloroform extract, c2: Chloroform extract (chalepensin), c3: Coumarin, c4: Coronaridine hydrochloride, c5: Crude fraction, d1: Distilled water extract, d2: Dichloromethane, e1 : Embelin, e2: Ether extract, e3 : Ethanolic extract, e4: Ethyl acetatem, f1: Fruit oil, f2: Flower extract, f3: Flavones (apigenin and luteolin), f4: Flavones (acacetin and luteolin), f5: Fatty acids, g1: Gossypol, g2: Glycosides, h1: Hexane extract, h2: Hydroalcoholic extract, h3: Hexane fraction, ip: Iso-propanolic extract, l1: Leaf juice, l2: Latex extract (aqueous), m1: Methanolic extract, m2: Methanolic extract (andrographolide), m3: Montanol, m4: Methanol:methylene chloride 1:1, m5: Methanol fraction, n1: Nut oil, n2: Neem oil, n3: Non-proteinaceous extract, o1: Oleoresin (acidic fraction), o2: Oleonolic acid,3-β Glucoside, p1: Plant extract, p2: Phenol and flavonoids, p3: Physalinx, p4: Petroleum ether extract, p5: P-coumaric, p6: Powder, r1: Resin, s1: Saponin fraction, s2: Steroidal extract, s3: Steroidal lactone (dq1), s4: Steroidal lactone, s5: Steroidal fraction, s6: Seed extract, s7: Seed oil, t1: Triterpenoid glycoside, u1: Uterotonic fraction, w1: Water soluble fraction of ethanolic extract, x1: Xylohydroquinone, z1: Zoapatanol, A1: Anti-implantation, A2: Abortifacient, A3: Anti-oestrogenic or interrupt oestrous cycle, A4: Antifertility or 100% sterility or inhibited fertility, A5: Anti-ovulatory, A6: Abrogate pregnancy (10%), A7: Alteration in reproductive organ weight, A8: Anti-conceptive, A9: 100% Activity, A10: Anti-zygotic, B1: Blocked pregnancy (pre-implantation block), B2: Blocked the uterotropic responses of exogenous estrogen, B3: Blastocidal, C1: Cyclicity disrupted in virgin, C1: Changes in biochemical profile of ovary and uterus, C3: Completely annulled the biological potency of hCG, C4: Complete inhibition of chorionic gonadotropin, C5: Cycle length prolonged, C6: Cholesterol, ascorbic acid of ovary is elevated, C7: Contraceptive efficacy, D1: Decrease in fertile mating and number of offspring, D2: Decrease no. of graafian follicle and corpora lutea, D3: Decrease in litter size, E1: Estrogenic activity or oestrogenic or estrogenicity, E2: Encouraging antifertility activity, E3: Estrogen induced alkaline phosphatase activity in the endometrium of immature rabbits, E4: Enhanced uterine contractibility, E5: Embryotoxic perinatally, F1: Follicular degeneration, F2: Reduction in No. of viable fetuses, F3: Fetal toxicity, G1: Altered gonadotropin release and estradiol secretion, H1: Histopathological changes in the ovary and uterus, l1: Inhibition of progesterone production (abortifacient), I2: Implantation sites decreased, I3: Increase in uterine, cervical and vaginal weights, I4: Irregular oestrous cycle, I5: Influences the sexual maturity of immature female rats, I6: Inhibited the action of hormone in hCG, I7: Inhibition of uterine activity, I8: Inhibition of delta 5, 3- β hydroxy steroid dehydrogenase and glucose-6-phosphodehydrogenase, I9: Inhibition of heat, I10: Increased progesterone concentration, I11: Inhibited uterine contractility, L1: Lower plasma level of oestradiol, L2: Lower body weight of pups, M1: Mild oestrogenic activity, N1: No effect, N2: No effect on progesterone response of uterus, P1: Prevent or protected or inhibit or interrupt pregnancy, P2: Partial to complete vaginal cornification, P3: Prolonged diestrous phase (prolonged oestrus cycle ), P4: Pregnant mare’s serum gonadotropin, P5: Post-coital contraceptive efficacy, R1: Resin- Rs: Reversible on withdrawal of treatment, R2: Reduction in weight of ovaries, uterus and cervix, R3: Resorption of implants, R4: Reversible on exogenous administration of hydroxy progesterone, R5: Reduction in fertility index, S1: Significant increase in body weight, Ts: Tetanic spasm, U1: Uterotonic, U2: Uterine stimulant, U3: Uterotropic activity, V1: Vagina open, showed cornified and epithelial cells, Pl: Whole plant, Ae Pl: Aerial plant part, Rt: Root, St: Stem, Lf: Leaves or leaf, Bk: Bark, Rt-Bk: Root bark, Bk: Stem bark, Rt Xy: Root xylem, Ep: Epigeal part, Fl: Flowers, Fr Pl: Fruit peel. Pe: Petals, Be: Berries, Fr: Fruit, Ri Fr: Ripe fruit, Ri Fr Ep: Ripe fruit epicarp, Gr Fr Ep: Green fruit epicarp, Un Fr Pu: Unripe fruit pulp, Un Fr Lx: Unripe fruit latex, Sl Fr: Stale fruit, Sd: Seed, sp: Serial part, Rh: Rhizome, Rg: Bulb, Bu: Resinous gum, Tu: Tuber, Ct: Crude papaya latex, Pc: Post-coitally, Ivg: Intravaginal, Iu: Intrauterine, Sc: Subcutaneous, Or: Oral, Ov: Overiectomised, b.wt.: Body weight, Ip: Intraperitoneum, d: Days, c: Cycle, gd: Gestation day, mc: Menstrual cycle

The study suggested that MSF was administered at doses of 50, 100, 250 and 500 mg kg–1 b.wt., day–1 for 4 weeks had no developmental toxicity and teratogenicity during implantation and gestation20. The MSF treatment at various dose regimens did not show significant changes in body and organs weight, feeding habit and pre-terminal deaths. Chromosomal aberrations were investigated in spermatogonial cells of albino rats and rabbits, following oral administration of Methanol Sub Fraction (MSF) of papaya seeds. The chromosomal fragments, rings, dicentrics, exchanges, damaged chromosomes and total chromosomal aberrations in MSF treated rats and rabbits did not showed any alterations21. Moreover, oral administration of Methanol Sub-Fraction (MSF) of benzene chromatographic fraction of the chloroform extract of papaya seeds had no lethal effect when administered at 20x CD (Contraceptive dose) for 5 consecutive days in albino rats and rabbits22.

CONCLUSION

The review showed that study for female fertility regulation is being carried out on a large number of plants and derived products. Consap as a spermicide has been licensed to the Hindustan Latex Limited, Mumbai to market the product. Clinical trials are on going with pippaliyadi vati. A microbicide praneem polyherbal tablet (PPHT), as a contraceptive and for management of abnormal vaginal discharge syndrome has been licensed to M/s Panacea Biotec. Carica papaya products may take a great lead as a dual contraceptive which has been found effective for both sexes. At last, for developing a contraceptive from a natural source, a well defined time-bound approach should be adapted.

SIGNIFICANT STATEMENT

The ancient literature described how plant and their derived products contributed in regulating fertility in females
In this review, status of research on plant derived agents is highlighted
The plant kingdom stills an essentially unused source of new fertility regulating agents

ACKNOWLEDGMENT

The authors are thankful to the Head, Department of Zoology, University of Rajasthan, Jaipur, India for providing facilities.

REFERENCES

  1. Garg, S.K., V.S. Mathur and R.R. Chaudhury, 1978. Screening of Indian plants for antifertility activity. Indian J. Exp. Biol., 16: 1077-1079.
    PubMed  |  Direct Link  |  


  2. Kulshreshtha, D.K. and S. Srivastava, 2001. New Leads for Female Fertility Regulation from Plants. In: Current Status in Fertility Regulation: Indeginous and Modern Approaches, Chaudhary, S.R., C.M. Gupta and V.P. Kamboj (Eds.). Central Drug Research Institute, Lucknow, pp: 133-158


  3. Chaudhury, R.R., 2001. Traditional Methods of Fertility Regulation. In: Current Status in Fertility Regulation: Indeginous and Modern Approaches, Chaudhary, S.R., C.M. Gupta and V.P. Kamboj (Eds.). Central Drug Research Institute, Lucknow, pp: 11-21


  4. Balasinor, N., A. Bhan, N.S. Paradkar, A. Shaikh, T.D. Nandedkar, K.K. Bhutani and M. Roy-Chaudhury, 2007. Postnatal development and reproductive performance of F1 progeny exposed in utero to an ayurvedic contraceptive: Pippaliyadi yoga. J. Ethnopharmacol., 109: 406-411.
    CrossRef  |  Direct Link  |  


  5. Dhar, J.D., V.K. Bajpai, B.S. Setty and V.P. Kamboj, 1989. Morphological changes in human spermatozoa as examined under scanning electron microscope after in vitro exposure to saponins isolated from Sapindus mukorossi. Contraception, 39: 563-568.
    CrossRef  |  Direct Link  |  


  6. Nivsarkar, M., N. Shrivastava, M. Patel, H. Padh and C. Bapu, 2002. Sperm membrane modulation by Sapindus mukorossi during sperm maturation. Asian J. Androl., 4: 233-235.
    Direct Link  |  


  7. Bhosale, V.V., O.P. Asthana and S.P.S. Gaur, 2013. Efficacy and safety of herbal spermicidal contraceptive Consap. Curr. Sci., 104: 1701-1703.
    Direct Link  |  


  8. Garg, S., V. Taluja, S.N. Upadhyay and G.P. Talwar, 1993. Studies on the contraceptive efficacy of Praneem polyherbal cream. Contraception, 48: 591-596.
    CrossRef  |  Direct Link  |  


  9. Joglekar, N.S., S.N. Joshi, S.S. Deshpande, A.N. Parkhe, U.R. Katti and S.M. Mehendale, 2010. Acceptability and adherence: Findings from a Phase II study of a candidate vaginal microbicide, Praneem polyherbal tablet, in Pune, India. Trans. R. Soc. Trop. Med. Hygiene, 104: 412-415.
    CrossRef  |  Direct Link  |  


  10. Talwar, G.P., P. Raghuvanshi and S. Gopalan, 2001. Praneem Polyherbal Formulation for Dual Purpose of Contraception and Prevention of Sexually Transmitted Diseases and Reproductive Tract Infections. In: Current Status in Fertility Regulation: Indigenous and Modern Approaches, Chowdhury, S.R., C.M. Gupta and V.P. Kamboj (Eds.). Central Drug Research Institute, Lucknow, pp: 91-98


  11. Joglekar, N.S., S.N. Joshi, S.N. Navlakha, U.R. Katti and S.M. Mehendale, 2006. Acceptability of Praneem polyherbal vaginal tablet among HIV uninfected women and their male partners in Pune India-Phase I study. Indian J. Med. Res., 123: 547-552.
    Direct Link  |  


  12. Bagga, R., P. Raghuvanshi, S. Gopalan, S.K. Das and R. Baweja et al., 2006. A polyherbal vaginal pessary with spermicidal and antimicrobial action: Evaluation of its safety. Trans. R. Soc. Trop. Med. Hygiene, 100: 1164-1167.
    CrossRef  |  Direct Link  |  


  13. Lohiya, N.K., B. Manivannan, P.K. Mishra and N. Pathak, 2001. Prospects of Developing a Plant Based Male Contraceptive Pill. In: Current Status in Fertility Regulation: Indigeneous and Modern Approaches, Chowdhury, S.R., C.M. Gupta and V.P. Kamboj (Eds.). Central Drug Research Institute, Lucknow, India, ISBN: 81-85042-17-9, pp: 99-119


  14. Kamal, R., R.S. Gupta and N.K. Lohiya, 2003. Plants for male fertility regulation. Phytother. Res., 17: 579-590.
    CrossRef  |  PubMed  |  Direct Link  |  


  15. Chopra, R.N., I.C. Chopra, K.L. Handa and L.D. Kapur, 1958. Chopra's Indigenous Drugs of India. Dhur and Sons Private Ltd., Calcutta, India


  16. Keharo, J. and A. Bouquet, 1950. Medicinal and Poisonous Plants in the Ivory Coast Upper Volta. Vigot Freres, Paris


  17. Quisumbing, E.A., 1951. Medicinal plants of the Philippines. Department of Agricultural and Natural Resources, Technical Bulletin No. 16, Philippines.


  18. Tang, C.S., 1979. Macrocyclic piperidine and piperiding alkaloid in Carica papaya. Food Chem. Nutr., 1: 55-68.


  19. Ferro-Luzzi, E.G., 1980. Food Avoidance of Pregnant Women in Tamil nadu. In: Food, Ecology and Culture: Reddings in the Anthropology of Dietay Practices, Robson, J.R.K. (Ed.). Gordon and Breach Science Publishers, New York, pp: 101-108


  20. Shrivastava, S., A.S. Ansari and N.K. Lohiya, 2011. Fertility, developmental toxicity and teratogenicity in albino rats treated with methanol sub-fraction of Carica papaya seeds. Indian J. Pharmacol., 43: 419-423.
    CrossRef  |  PubMed  |  Direct Link  |  


  21. Ansari, A.S., S. Shrivastava, S. Goyal and N.K. Lohiya, 2011. Observations on chromosomal aberrations following the administration of methanol Sub-Fraction of Carica papaya seeds for contraception in albino rats and rabbits. Int. J. Pharmacol., 7: 721-725.
    CrossRef  |  Direct Link  |  


  22. Ansari, A.S., S. Shrivastava and N.K. Lohiya, 2011. Dominant lethal assay following administration of methanol sub-fraction of the seeds of Carica papaya. Pharmacologia, 2: 229-236.
    Direct Link  |  


  23. Pakrashi, A., N. Mookerji and B. Basak, 1975. Effect of chromatographic fractions of the plant Achyranthes aspera Linn. on fertility in female albino mice. J. Reprod. Fertil., 43: 127-128.
    Direct Link  |  


  24. Maurya, R., S. Srivastava, D.K. Kulshreshta and C.M. Gupta, 2004. Traditional remedies for fertility regulation. Curr. Med. Chem., 11: 1431-1450.
    CrossRef  |  PubMed  |  Direct Link  |  


  25. Wadhwa, M., 1982. Contraceptive effect of phytosteroids in female albino rats. Ph.D. Thesis, University of Rajasthan, Jaipur.


  26. Zia-Ul-Haque, A., M.H. Qazi and M.E. Hamdard, 1983. Studies on the antifertility properties of active components isolated from the seeds of Abrus precatorius Linn II. Pak. J. Zool., 15: 141-146.
    Direct Link  |  


  27. Abu, S.M., H.A. Manirul, M.A. Majid and I.M. Anwarul, 2012. Antifertility studies on ethanolic extract of Abrus precatorius L on swiss male albino mice. Int. J. Pharmaceut. Sci. Res., 3: 288-292.
    Direct Link  |  


  28. Ahirwar, D., 2011. Anti fertility activity of Acacia leucophploea. Scholars Res. Library, 3: 411-413.


  29. Hiremath, S.P., K. Rudresh, S. Badami, S.B. Patil and S.R. Patil, 1999. Post-coital antifertility activity of Acalypha indica L. J. Ethnopharmacol., 67: 253-257.
    CrossRef  |  Direct Link  |  


  30. Nana, P., E.A. Asongalem, H.S. Foyet, G.N. Folefoc, T. Dimo and P. Kamtchouing, 2008. Maternal and developmental toxicity evaluation of Acanthus montanus leaves extract administered orally to Wistar pregnant rats during organogenesis. J. Ethnopharmacol., 116: 228-233.
    CrossRef  |  PubMed  |  Direct Link  |  


  31. Asongalem, E.A., P. Nana, H.S. Foyet, T. Dimo and P. Kamtchouing, 2008. Antifertility and fetotoxic activities of Acanthus montanus aqueous extract in wistar rats. Methods Find. Exp. Clin. Pharmacol., 30: 521-528.
    CrossRef  |  PubMed  |  Direct Link  |  


  32. Dalsenter, P.R., A.M. Cavalcanti, A.J. Andrade, S.L. Araujo and M.C. Marques, 2004. Reproductive evaluation of aqueous crude extract of Achillea millefolium L. (Asteraceae) in Wistar rats. Reproduct. Toxicol., 18: 819-823.
    CrossRef  |  Direct Link  |  


  33. Dhawan, B.N., G.K. Patnaik, R.P. Rastogi, K.K. Singh and J.S. Tandon, 1977. Screening of Indian plants for biological activity: Part VI. Indian J. Exp. Biol., 15: 208-219.
    PubMed  |  Direct Link  |  


  34. Dhar, J.D., B.S. Setty, V. Lakshmi and D.S. Bhakuni, 1992. Post-coital antifertility activity of the marine plant, Achrostichum aureum L. in rat. Indian J. Med. Res., 96: 150-152.
    PubMed  |  Direct Link  |  


  35. Pakrashi, A. and N. Bhattacharya, 1977. Abortifacient principle of Achyranthes aspera Linn. Indian J. Exp. Biol., 15: 856-861.
    PubMed  |  Direct Link  |  


  36. Wadhwa, V., M.M. Singh, D.N. Gupta, C. Singh and V.P. Kamboj, 1986. Contraceptive and hormonal properties of Achyranthes aspera in rats and hamsters. Planta Medica, 52: 231-233.
    CrossRef  |  PubMed  |  Direct Link  |  


  37. Kamboj, V.P., 1988. A review of Indian medicinal plants with interceptive activity. Ind. J. Med. Res., 87: 336-355.
    PubMed  |  Direct Link  |  


  38. Vasudeva, N. and S.K. Sharma, 2006. Post-coital antifertility activity of Achyranthes aspera Linn. root. J. Ethnopharmacol., 107: 179-181.
    CrossRef  |  PubMed  |  Direct Link  |  


  39. Shibeshi, W., E. Makonnen, A. Debella and L. Zerihun, 2006. Phytochemical, contraceptive efficacy and safety evaluations of the methanolic leaves extract of Achyranthes aspera L. in rats. Pharmacologyonline, 3: 217-224.
    Direct Link  |  


  40. Gupta, O.P., K.K. Anand, B.J. Ghatak and C.K. Atal, 1978. Vasicine, alkaloid of Adhatoda vasica, a promising uterotonic abortifacient. Indian J. Exp. Biol., 16: 1075-1077.
    PubMed  |  Direct Link  |  


  41. Lal, R. and P.L. Sharma, 1981. Potential of prostaglandins evoked contractions of isolated rat uterus by Vasicine hydrochloride. Indian J. Med. Res., 73: 641-648.


  42. Nath, D., N. Sethi, R.K. Singh and A.K. Jain, 1992. Commonly used Indian abortifacient plants with special reference to their teratologic effects in rats. J. Ethnopharmacol., 36: 147-154.
    CrossRef  |  Direct Link  |  


  43. Savadi, R. and K. Alagawadi, 2009. Antifertility activity of ethanolic extracts of Plumbago indica and Aerva lanata on albino rats. Int. J. Green Pharm., 3: 230-233.
    Direct Link  |  


  44. Dhanasekaran, S., B. Suresh, M. Sethuraman, S. Rajan and R. Dubey, 1993. Antifertility activity of Ailanthus excelsa Linn. in female albino rats. Indian J. Exp. Biol., 31: 384-385.
    Direct Link  |  


  45. Ravichandran, V., B. Suresh, M.N. Sathishkumar, K. Elango and R. Srinivasan, 2007. Antifertility activity of hydroalcoholic extract of Ailanthus excelsa (Roxb): An ethnomedicines used by tribals of Nilgiris region in Tamilnadu. J. Ethnopharmacol., 112: 189-191.
    CrossRef  |  Direct Link  |  


  46. Murugan, V., H. Shareef, G.V.S. Ramasharma, M. Ramanathan and B. Suresh, 2000. Anti-fertility activity of the stem bark of Alangium salvifolium (Linn.F) wang in wistar female rats. Indian J. Pharmacol., 32: 388-389.
    Direct Link  |  


  47. Gupta, M.L., T.K. Gupta and K.P. Bhargava, 1971. A study of antifertility effects of some indigeneous drugs. J. Res. Ind. Med., 6: 112-117.
    Direct Link  |  


  48. Vohra, S.B., M.S.Y. Khan and S.H. Afia, 1973. Antifertility studies on Unani herbs Part III antiovulatory effects of Honzal, Halun, Kalongi, Sambhalu (Vitex negundo). Indian J. Pharm., 35: 100-102.


  49. Thakare, V.N., P.S. Kothavade, V.V. Dhote and A.D. Deshpande, 2009. Antifertility activity of ethanolic extract of Allium cepa Linn in rats. Int. J. PharmTech Res., 1: 73-78.
    Direct Link  |  


  50. Bhaduri, B., C.R. Ghosh, A.N. Bose, B.K. Moza and B.P. Basu, 1968. Antifertility activity of some medicinal plants. Indian J. Exp. Biol., 6: 252-253.
    PubMed  |  Direct Link  |  


  51. Gurumani, M. and K. Balamurugan, 2013. Evaluation of antifertility potential of ethanolic extract of whole plant of Amaranthus spinosus in female albino rats. World J. Pharm. Pharmaceut. Sci., 3: 2162-2167.
    Direct Link  |  


  52. Dhanapal, R., S. Kavimani, V. Swamy, B. Matha and M. Gupta et al., 2005. Antisteroidogenic activity of ethanol extract of Ammania baccifera (L.) whole plant in female albino mice ovaries. Iran. J. Pharmacol. Therapeut., 4: 43-45.
    Direct Link  |  


  53. Pakrashi, A. and B. Basak, 1976. Abortifacient effect of steroids from Ananas comosus and their analogues on mice. J. Reprod. Fertil., 46: 461-462.
    CrossRef  |  Direct Link  |  


  54. Zoha, M.S., A.H. Hussain and S.A. Choudhury, 1989. Antifertility effect of Andrographis paniculata in mice. Bangladesh Med. Res. Counc. Bull., 15: 34-37.
    PubMed  |  Direct Link  |  


  55. Monsefi, M., M. Ghasemi and A. Bahaoddini, 2006. The effects of Anethum graveolens L. on female reproductive system. Phytother. Res., 20: 865-868.
    CrossRef  |  PubMed  |  Direct Link  |  


  56. Saluja, A.K. and D.D. Santani, 1984. Antifertility activity of Xeromphis spinosa and Annona squamosa. Indian J. Pharmaceut. Sci., 46: 21-23.
    Direct Link  |  


  57. Damasceno, D.C., G.T. Volpato, T.C.F. Sartori, P.F. Rodrigues, E.A. Perin, I.M.P. Calderon and M.V.C. Rudge, 2002. Effects of Annona squamosa extract on early pregnancy in rats. Phytomedicine, 9: 667-672.
    CrossRef  |  Direct Link  |  


  58. Garg, S.K. and G.P. Garg, 1971. Antifertility screening of plants: Part 7. Effect of 5 indigenous plants on early pregnancy in albino rats. Indian J. Med. Res., 59: 302-306.
    Direct Link  |  


  59. Garg, S.K., 1974. Antifertility effect of oil from few indigenous plants on female albino rats. Planta Medica, 26: 391-393.
    CrossRef  |  PubMed  |  Direct Link  |  


  60. Nataraj, S.K.M., P.K. Puvvada, S. Badami, S.B. Patil and E. Kannan et al., 2007. Pre-coital and post-coital anti-implantation and abortifacient activities of Aristolochia bracteolata Lam. aerial parts. J. Nat. Med., 61: 302-306.
    CrossRef  |  Direct Link  |  


  61. Pakrashi, A. and C. Shaha, 1977. Effect of a sesquiterpene from Aristolochia indica Linn. on fertility in female mice. Experientia, 33: 1498-1499.
    CrossRef  |  Direct Link  |  


  62. Pakrashi, A. and B. Chakrabarty, 1978. Anti-oestrogenic and anti-implantatin effect of aristolic acid from Aristolochia indica (Linn.). Indian J. Exp. Biol., 16: 1283-1285.
    PubMed  |  Direct Link  |  


  63. Pakrashi, A. and P. Pakrasi, 1979. Antifertility efficacy of the plant Aristolochia indica Linn. on mouse. Contraception, 20: 49-54.
    CrossRef  |  Direct Link  |  


  64. Pal, A.K., S.N. Kabir and A. Pakrashi, 1982. A probe into the possible mechanism underlying the interceptive action of aristolic acid. Contraception, 25: 639-648.
    CrossRef  |  Direct Link  |  


  65. Ganguly, T., A. Pakrashi and A.K. Pal, 1986. Disruption of pregnancy in mouse by aristolic acid: I. Plausible explanation in relation to early pregnancy events. Contraception, 34: 625-637.
    CrossRef  |  Direct Link  |  


  66. Prakash, A.O. and R. Mathur, 1977. Effect of Artobotrys odoratissimus Linn. extracts on oestrus cycle, body weight and uterine weight in albino rats. Indian J. Exp. Biol., 15: 1038-1040.
    Direct Link  |  


  67. Shaik, A., R.S. Kanhere, R. Cuddapah, K.S. Nelson, P.R. Vara and S. Sibyala, 2014. Antifertility activity of Artemisia vulgaris leaves on female Wistar rats. Chin. J. Nat. Med., 12: 180-185.
    CrossRef  |  Direct Link  |  


  68. Tafesse, G., Y. Mekonnen and E. Makonnen, 2006. Antifertility effect of aqueous and ethanol extracts of the leaves and roots of Asparagus africanus in rats. Afr. Health Sci., 6: 81-85.
    Direct Link  |  


  69. Nwafor, P.A., F.K. Okwuasaba and O.O. Onoruwe, 1998. Contraceptive and non-estrogenic effects of methanolic extract of Asparagus pubescens root in experimental animals. J. Ethnopharmacol., 62: 117-122.
    CrossRef  |  Direct Link  |  


  70. Oyesola, T.O., O.A. Oyesola and C.S. Okoye, 2010. Effects of aqueous extract of Aspilia africana on reproductive functions of female wistar rats. Pak. J. Biol. Sci., 13: 126-131.
    CrossRef  |  Direct Link  |  


  71. Chandhoke, N., 1979. Scoparone: Effect on reproductive processes in rats. Indian J. Exp. Biol., 17: 740-742.
    PubMed  |  


  72. Lal, R., A. Sankaranarayanan, V.S. Mathur and P.L. Sharma, 1986. Antifertility effect of neem oil in female albino rats by the intravaginal and oral routes. Indian J. Med. Res., 83: 89-92.
    PubMed  |  


  73. Riar, S.S., J. Bardhan, P. Thomas, A.K. Kain and R. Parshad, 1988. Mechanism of antifertility action of neem oil. Indian J. Med. Res., 88: 339-342.
    PubMed  |  


  74. Upadhyay, S.N., C. Kaushic and G.P. Talwar, 1990. Antifertility effects of neem (Azadirachta indica) oil by single intrauterine administration: A novel method for contraception. Proc. R. Soc. London B: Biol. Sci., 242: 175-179.
    CrossRef  |  Direct Link  |  


  75. Mukherjee, S., S. Garg and G.P. Talwar, 1999. Early post implantation contraceptive effects of a purified fraction of neem (Azadirachta indica) seeds, given orally in rats: Possible mechanisms involved. J. Ethnopharmacol., 67: 287-296.
    CrossRef  |  Direct Link  |  


  76. Roop, J.K., P.K. Dhaliwal and S.S. Guraya, 2005. Extracts of Azadirachta indica and Melia azedarach seeds inhibit folliculogenesis in albino rats. Braz. J. Med. Biol. Res., 38: 943-947.
    PubMed  |  Direct Link  |  


  77. Gbotolorun, S.C., A.A. Osinubi, C.C. Noronha and A.O. Okanlawon, 2008. Antifertility potential of Neem flower extract on adult female Sprague-Dawley rats. Afr. Health Sci., 8: 168-173.
    Direct Link  |  


  78. Padmashali, B., V.P. Vaidya, H.M. Vagdevi and N.D. Satyanarayana, 2006. Antifertility efficacy of the plant Balanites roxburghii (Balanitaceae) in female rats. Indian J. Pharmaceut. Sci., 68: 347-351.
    Direct Link  |  


  79. Bandyopadhyay, S., 2010. Anti-fertility activity of methanol extract of Bassia latifolia and Cajanus cajan in female albino mice ovaries. Iran. J. Pharmacol. Therapeut., 9: 83-87.
    Direct Link  |  


  80. Mishra, N., S. Joshi, V.L. Tandon and A. Munjal, 2009. Evaluation of anti-fertility potential of aqueous extract of Bougainvillea spectabilis leaves in Swiss albino mice. Int. J. Pharmaceut. Sci. Drug Res., 1: 19-23.
    Direct Link  |  


  81. Matadial, L., M.E. West, M. Gossell-Williams and T.L. The, 1999. The effect of Bromelia pinguin extract on the pregnant rat uterus. West Indian Med. J., 48: 198-199.
    PubMed  |  Direct Link  |  


  82. Kapila, K., N.K. Bhide and M.K. Razdan, 1970. The antifertility effect of Butea frondosa petals (alcoholic extract and its crystalline fraction). J. Indian Med. Assoc., 55: 60-61.
    Direct Link  |  


  83. Razdan, M.K., K. Kapila and N.K. Bhide, 1969. Antifertility effect and some pharmacological actions of Butea frondosa seed extracts. Indian J. Physiol. Pharmacol., 13: 239-249.
    PubMed  |  


  84. Khanna, U., S. Handa and R.R. Chaudhary, 1966. The effect of Butea monosperma (Lam) kuntze on the fertility of female rats. Indian J. Pharmacy, 28: 343-348.
    Direct Link  |  


  85. Sharma, S.K., G. Rai and N. Vasudeva, 2012. Anti-fertility investigation of Butea monosperma (Lam.) kuntze root in female albino mice. Res. J. Med. Plant, 6: 260-266.
    CrossRef  |  Direct Link  |  


  86. Kholkute, S.D., V. Mudgal and P.J. Deshpande, 1976. Screening of indigenous medicinal plants for antifertility potentiality. Planta Medica, 29: 151-155.
    CrossRef  |  PubMed  |  Direct Link  |  


  87. Bhargava, S.K., 1986. Estrogenic and postcoital anticonceptive activity in rats of butin isolated from Butea monosperma seed. J. Ethnopharmacol., 18: 95-101.
    CrossRef  |  PubMed  |  Direct Link  |  


  88. Kumar, S., J. Singh, A. Baghotia, V. Mehta and V. Thakur et al., 2013. Antifertility potential of the ethanolic extract of Caesalpinia pulcherrima Linn. leaves. Asian Pac. J. Reprod., 2: 90-92.
    CrossRef  |  Direct Link  |  


  89. Khanna, U., S.L. Garg, S.B. Vohra, H.B. Walia and R.R. Chaudhury, 1969. Antifertility screening of plants: Part 2. Effect of 6 indigenous plants on early pregnancy in albino rats. Indian J. Med. Res., 57: 237-244.
    Direct Link  |  


  90. Vohora, S.B., S.K. Garg and R.R. Chaudhury, 1969. Antifertility screening of plants. 3. Effect of six indigenous plants on early pregnancy in albino rats. Indian J. Med. Res., 57: 893-897.
    PubMed  |  


  91. Saksena, S.K., S.K. Garg and R.R. Chaudhury, 1970. Antifertility screening of plants. Part V: Effect of six indigenous plants on early pregnancy in albino rats. Indian J. Med. Res., 58: 253-257.
    PubMed  |  Direct Link  |  


  92. Srivastava, S.R., G. Keshri, B. Bhargavan, C. Singh and M.M. Singh, 2007. Pregnancy interceptive activity of the roots of Calotropis gigantea Linn. in rats. Contraception, 75: 318-322.
    CrossRef  |  Direct Link  |  


  93. Kamath, J.V. and A.C. Rana, 2002. Preliminary study on antifertility activity of Calotropis procera roots in female rats. Fitoterapia, 73: 111-115.
    CrossRef  |  Direct Link  |  


  94. Zade, V., M. Dhore, D. Dabhadkar, S. Pare, M. Wikhe, V. Deshmukh and S. Chede, 2013. Indigenous herbal remedies used by Tribals of Melghat region of Amravati district for regulation of antifertility and aphrodisiac activity. Int. J. Res. Pharmaceut. Biomed. Sci., 4: 1104-1109.
    Direct Link  |  


  95. Kalita, J.C., A. Haque, E. Kalita, R. Sharma and M.M. Rahman, 2011. Anti-fertility effects of the methanolic root extract of Careya arborea Roxb in albino mice. BioScan, 6: 701-706.
    Direct Link  |  


  96. Haloi, A.K., E. Kalita and J.C. Kalita, 2010. Effects of methanolic root extract of Careya arborea Roxb. on ovarian histology of albino mice. NeBIO: Int. J. Environ. Biodivers., 1: 14-17.


  97. Devi, S. and S. Singh, 1978. Changes in placenta of rat fetuses induced by maternal administration of papain. Indian J. Exp. Biol., 16: 1256-1260.
    PubMed  |  Direct Link  |  


  98. Gopalakrishnan, M. and M.R. Rajasekharasetty, 1978. Effect of papaya (Carica papaya Linn) on pregnancy and estrous cycle in albino rats of Wistar strain. Indian J. Physiol. Pharmacol., 22: 66-70.
    PubMed  |  


  99. Singh, S. and K. Singh, 1992. Anti-implantation effect of Carica papaya seed powder in female albino rats. Indian J. Phys. Nat. Sci., 11-12: 73-78.


  100. Chinoy, N.J., T. Dilip and J. Harsha, 1995. Effect of Carica papaya seed extract on female rat ovaries and uteri. Phytother. Res., 9: 169-175.
    CrossRef  |  Direct Link  |  


  101. Schmidt, H., 1995. Effect of papain on different phases of prenatal ontogenesis in rats. Reprod. Toxicol., 9: 49-55.
    CrossRef  |  Direct Link  |  


  102. Chinoy, N.J., J. Harsha and G. Shilpa, 1997. Antifertility investigations of alcoholic papaya seed extract in female rats. J. Med. Aromatic Plant Sci., 19: 422-427.


  103. Mishra, P.K., N. Pathak, B. Manivannan and N.K. Lohiya, 2000. Screening for the hormonal properties of the chloroform extract of Carica papaya Linn. seeds for antifertility investigation. Nat. Prod. Sci., 6: 5-10.
    Direct Link  |  


  104. Adebiyi, A., P.G. Adaikan and R.N.V. Prasad, 2002. Papaya (Carica papaya) consumption is unsafe in pregnancy: Fact or fable? Scientific evaluation of a common belief in some parts of Asia using a rat model. Br. J. Nutr., 88: 199-203.
    Direct Link  |  


  105. Oderinde, O., C. Noronha, A. Oremosu, T. Kusemiju and O.A. Okanlawon, 2002. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger. Postgraduate Med. J., 9: 95-98.
    PubMed  |  


  106. Raji, Y., A.O. Morakinyo, O.S. Akinsomisoye, A.K. Oloyo, P.R.C. Esegbue-Peters and O.T. Kunle-Alabi, 2006. Evaluation of the abortifacient properties of chloroform extract of Carica papaya L. seed in female albino rats. Int. J. Pharmacol., 2: 20-23.
    CrossRef  |  Direct Link  |  


  107. Anuar, N.S., S.S. Zahari., I.A. Taib and M.T. Rahman, 2008. Effect of green and ripe Carica papaya epicarp extracts on wound healing and during pregnancy. Food Chem. Toxicol., 46: 2384-2389.
    CrossRef  |  PubMed  |  Direct Link  |  


  108. Thakur, S., B. Bawara, A. Dubey, D. Nandini, N.S. Chauhan and D.K. Saraf, 2009. Effect of Carum carvi and Curcuma longa on hormonal and reproductive parameter of female rats. Int. J. Phytomed., 1: 31-38.
    Direct Link  |  


  109. Bhardwaj, S., R. Mathur and O.P. Agrawal, 1980. Estrogenicity of fruits of Cassia fistula Linn. and its effects on implantation in female albino rats. Bull. Med. Ethnobot. Res., 1: 281-284.
    Direct Link  |  


  110. Yadav, R. and G.C. Jain, 1999. Antifertility effect of aqueous extract of seeds of Cassia fistula in female rats. Adv. Contraception, 15: 293-301.
    CrossRef  |  Direct Link  |  


  111. Chauhan, A. and M. Agarwal, 2010. Evaluating the antifertility potential of an aqueous extract from Cassia fistula seeds in male rats. Fertil. Steril., 93: 1706-1710.
    CrossRef  |  Direct Link  |  


  112. Nwafor, P.A. and F.K. Okwuasaba, 2001. Contraceptive and estrogenic effect of a methanol extract of Cassia nigricans leaves in experimental animals. Pharmaceut. Biol., 39: 424-428.
    CrossRef  |  Direct Link  |  


  113. Prakash, A.O. and R. Mathur, 1976. Screening of Indian plants for antifertility activity. Indian J. Exp. Biol., 14: 623-626.
    PubMed  |  


  114. Keshri, G., V. Lakshmi and M.M. Singh, 1998. Postcoital contraceptive activity of some indigenous plants in rats. Contraception, 57: 357-360.
    CrossRef  |  Direct Link  |  


  115. Cherian, T., 2000. Effect of papaya latex extract on gravid and non-gravid rat uterine preparations in vitro. J. Ethnopharmacol., 70: 205-212.
    CrossRef  |  Direct Link  |  


  116. Zierau, O., C. Bodinet, S. Kolba, M. Wulf and G. Vollmer, 2002. Antiestrogenic activities of Cimicifuga racemosa extracts. J. Steroid Biochem. Mol. Biol., 80: 125-130.
    CrossRef  |  Direct Link  |  


  117. Ganguly, M., M.K. Borthakur, N. Devi and R. Mahanta, 2007. Antifertility activity of the methanolic leaf extract of Cissampelos pareira in female albino mice. J. Ethnopharmacol., 111: 688-691.
    CrossRef  |  Direct Link  |  


  118. Samanta, J. and S. Bhattacharya, 2011. Cissampelos pareira: A promising antifertility agent. Int. J. Res. Ayurveda Pharm., 2: 439-442.
    Direct Link  |  


  119. Piyachaturawat, P., T. Glinsukon and A. Chanjarunee, 1985. Antifertility effect of Citrus hystrix DC. J. Ethnopharmacol., 13: 105-110.
    CrossRef  |  Direct Link  |  


  120. Kulkarni, T.R., M.A. Kothekar and M. Mateenuddin, 2005. Study of anti-fertility effect of lemon seeds (Citrus limonum) in female albino mice. Indian J. Physiol. Pharmacol., 49: 305-312.
    Direct Link  |  


  121. Kachroo, M. and S.S. Agrawal, 2011. Anti-implantation activity of different extract of the peels of Citrus medica, Linn. Int. J. PharmTech Res., 3: 535-539.
    Direct Link  |  


  122. Patil, S.J and S.B. Patil, 2013. Antiovulatory activity of petroleum ether extract of chromatographic fractions of Citrus medica seeds in albino rats. J. Med. Sci., 13: 410-417.
    CrossRef  |  Direct Link  |  


  123. Patil, S.J., S.R. Banagar, R.R. Banagar, S. Venkatesh, T. Vishwanatha and S.B. Patil, 2013. Withdrawal antifertility effect of petroleum ether extract of Citrus medica seeds in female albino rats. Med. Plants: Int. J. Phytomed. Relat. Ind., 5: 75-81.
    CrossRef  |  Direct Link  |  


  124. Kumar, D., A. Kumar and O. Prakash, 2010. Post-coital antifertility activity of Clerodendrum phlomidis Linn. dichloromethane root extract. Pharmacologyonline, 3: 479-485.
    Direct Link  |  


  125. Yakubu, M.T., M.A. Akanji, A.T. Oladiji, A.O. Olatinwo and A.A. Adesokan et al., 2008. Effect of Cnidoscolous aconitifolius (Miller) I.M. Johnston leaf extract on reproductive hormones of female rats. Iran. J. Reprod. Med., 6: 149-155.
    Direct Link  |  


  126. Tzeng, H.P., W. Chiang, T.H. Ueng and S.H. Liu, 2005. The abortifacient effects from the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf. J. Toxicol. Environ. Health Part A, 68: 1557-1565.
    CrossRef  |  Direct Link  |  


  127. Benie, T., A. El Izzi, C. Tahiri, J. Duval and M.L. Thieulant, 1990. Combretodendron africanum bark extract as an antifertility agent. I: Estrogenic effects in vivo and LH release by cultured gonadotrope cells. J. Ethnopharmacol., 29: 13-23.
    CrossRef  |  PubMed  |  Direct Link  |  


  128. Amma, M.K., N. Malhotra, R.K. Suri, O.P. Aryc, H.M. Dani and K. Sareen, 1978. Effect of oleo resin of gum guggul (Commiphora mukul) on the reproductive organs of female rat. Indian J. Exp. Biol., 16: 1021-1023.
    PubMed  |  Direct Link  |  


  129. Gupta, M., U.K. Mazumder, D.K. Pal and S. Bhattacharya, 2003. Anti-steroidogenic activity of methanolic extract of Cuscuta reflexa roxb. stem and Corchorus olitorius Linn. seed in mouse ovary. Indian J. Exp. Biol., 41: 641-644.
    PubMed  |  Direct Link  |  


  130. Al-Said, M.S., K.I. Al-Khamis, M.W. Islam, N.S. Parmar, M. Tariq and A.M. Ageel, 1987. Post-coital antifertility activity of the seeds of Coriandrum sativum in rats. J. Ethnopharmacol., 21: 165-173.
    CrossRef  |  PubMed  |  Direct Link  |  


  131. Singh, S., A.K. Sanyal, S.K. Bhattacharya and V.B. Pandey, 1972. Oestrogenic activity of saponins from Costus speciosus (Koen) Sm. Indian J. Med. Res., 60: 287-290.
    PubMed  |  Direct Link  |  


  132. Tewari, P.V., C. Chaturvedi and V.B. Pandey, 1973. Anti-fertility activity of Costus speciosus. Indian J. Pharmacol., 35: 114-117.


  133. Rao, V.S., P. Dasaradhan and K.S. Krishnaiah, 1979. Antifertility effect of some indigenous plants. Indian J. Med. Res., 70: 517-520.
    PubMed  |  Direct Link  |  


  134. Rao, V.S.N. and K.S. Krishnaiah, 1979. Antifertility screening of plant effect of some reputed abortifacient indigenous plants on early pregnancy in rats. Indian J. Pharmacol., 11: 59-62.


  135. Vijaykumar, B.M., I. Sangamma, A. Sharanabasappa and S.B. Patil, 2004. Effect of Crotalaria juncea seed extracts on the estrous cycle and ovarian activity in albino mice. Orient. Pharm. Exp. Med., 4: 77-81.
    CrossRef  |  Direct Link  |  


  136. Malashetty, V.B. and S.B. Patil, 2007. Effect of chromatographic fractions of ethanolic extract of Crotalaria juncea (L.) seeds on ovarian follicular kinetics and estrous cycle in albino rats. Iran. J. Pharmacol. Therapeut., 6: 159-163.
    Direct Link  |  


  137. Bhaskar, V.H., K.M. Profulla, B.R. Balakrishnan, N. Balakrishnan and B. Sangameswaran, 2009. Evaluation of the anti-fertility activity of stem bark of Crataeva nurvala buch-ham. Afr. J. Biotechnol., 8: 6453-6456.
    Direct Link  |  


  138. Gupta, M., U.K. Mazumder, M.L.M. Vamsi, T. Sivakumar and C.C. Kandar, 2004. Anti-steroidogenic activity of the two Indian medicinal plants in mice. J. Ethanopharmacol., 90: 21-25.
    CrossRef  |  Direct Link  |  


  139. Garg, S.K., 1976. Antifertility screening of plants-effect of four indigenous plants on early pregnancy in female albino rats. Indian J. Med. Res., 64: 1133-1135.
    Direct Link  |  


  140. Kant, A., N.K. Lohiya and D. Jacob, 1988. The oestrogenicity of cumin (Cuminum cyminum) seeds in the ovariectomized rat. Indian Zool., 12: 209-213.


  141. Atkinson, W.M.B. and H. Elftman, 1947. Mobilization of alkaline phosphatase in the uterus of the mouse by estrogen. Endocrinology, 40: 30-36.
    CrossRef  |  PubMed  |  Direct Link  |  


  142. Trishna, D., M.S. Bhushan, B. Mrinmoy, J.P. Mohanty and S. Dibyendu, 2010. Evaluation of phytochemical screening and anti-fertility activity of Curcuma aromatica Salisb. Int. J. Pharmaceut. Sci. Res.
    Direct Link  |  


  143. Ghosh, A.K., A.K. Das and K.K. Patra, 2011. Studies on antifertility effect of rhizome of Curcuma longa Linn. Asian J. Pharm. Life Sci., 1: 349-353.
    Direct Link  |  


  144. Mishra, R.K. and S.K. Singh, 2009. Reversible antifertility effect of aqueous rhizome extract of Curcuma longa L. in male laboratory mice. Contraception, 79: 479-487.
    CrossRef  |  PubMed  |  Direct Link  |  


  145. Nayanatara, A.K., A. Alva, S. Kottari, A.A. Soofi and E.P. Rejeesh et al., 2012. Effect of cynodon dactylon extract on estrous cycle and reproductive organs in female Wistar rats. Int. J. Anal. Biomed. Pharm. Sci., 1: 10-15.
    Direct Link  |  


  146. Uchendu, C.N., T.N. Kamalu and I.U. Asuzu, 2000. A preliminary evaluation of antifertility activity of a triterpenoid glycoside (DSS) from Dalbergia saxatilis in female wistar rats. Pharmacol. Res., 41: 521-525.
    CrossRef  |  Direct Link  |  


  147. Pandiarajan, G., R. Govindaraj, K.B. Makesh and K. Sankarasivaraman, 2012. Antifertility activity in the acetone extracts of Datura metel L. seeds on female mouse. J. Pharmacogenom. Pharmacoproteom., Vol. 3.
    Direct Link  |  


  148. Chandhoke, N. and S. Gupta, 1978. Estrogenic activity of DQ1-a steroidal lactone-isolated from Datura quercifolia. Indian J. Exp. Biol., 16: 648-652.
    PubMed  |  Direct Link  |  


  149. Chandhoke, N., A. Gupta and S. Dhar, 1978. Interceptive activity of various species of piper, their natural amides and semi-synthetic analogs. Indian J. Pharm. Sci., 48: 113-118.
    Direct Link  |  


  150. Garg, S.K. and V.S. Mathur, 1972. Effect of chromatographic fractions of Daucus carota Linn. (seeds) on fertility in female albino rats. J. Reprod. Fertil., 31: 143-145.
    CrossRef  |  Direct Link  |  


  151. Sharma, M.M., G. Lal and D.S. Jacob, 1976. Estrogenic and pregnancy interceptory effects of carrot Daucus carota seeds. Indian J. Exp. Biol., 14: 506-508.
    Direct Link  |  


  152. Kaliwal, B.B., R.N. Ahamed and M.A. Rao, 1984. Dose and temporal effect of carrot seed (Daucus carota) extract on pregnancy in albino rats. Compar. Physiol. Ecol., 9: 173-177.
    Direct Link  |  


  153. Kant, A., D. Jacob and N.K. Lohiya, 1986. The estrogenic efficacy of carrot (Daucus carota) seeds. J. Adv. Zool., 7: 36-41.


  154. Kant, A.K., N.K. Lohiya and J. Dennis, 1989. A revolution of the pregnancy interceptory efficacy of carrot (Daucus carota) seeds in the rat. J. Adv. Zool., 10: 110-113.


  155. Majumder, P.K., S. Dasgupta, R.K. Mukhopadhaya, U.K. Mazumdar and M. Gupta, 1997. Anti-steroidogenic activity of the petroleum ether extract and fraction 5 (fatty acids) of carrot (Daucus carota L.) seeds in mouse ovary. J. Ethnopharmacol., 57: 209-212.
    CrossRef  |  PubMed  |  Direct Link  |  


  156. Pattanayak, S.P. and P.M. Mazumder, 2009. Effect of Dendrophthoe falcata (L.f.) Ettingsh on female reproductive system in Wistar rats: A focus on antifertility efficacy. Contraception, 80: 314-320.
    CrossRef  |  Direct Link  |  


  157. Badami, S., R. Aneesh, S. Sankar, M.N. Sathishkumar, B. Suresh and S. Rajan, 2003. Antifertility activity of Derris brevipes variety coriacea. J. Ethnopharmacol., 84: 99-104.
    CrossRef  |  Direct Link  |  


  158. Govindaraj, Y., V. Melanaphuru, S. Gupta, V. Agrahari and R.K. Nema, 2009. Antifertility activity of the ethanolic extract of Cassia occidentalis, Derris brevipes variety Brevipes and Justicia simplex. World J. Chem., 4: 118-122.
    Direct Link  |  


  159. De Pasquale, R.C., S. Ragusa, C. Circosta and A.M. Forestieri, 1984. Investigations on Dieffenbachia amoena Gentil. I: Endocrine effects and contraceptive activity. J. Ethnopharmacol., 12: 293-303.
    CrossRef  |  PubMed  |  Direct Link  |  


  160. Kitchlu, S., P.K. Mehrotra and S. Singh, 1999. Progesterone potentiating effect of Dipsacus mitis D. Don for its contraceptive action in hamster. Indian J. Exp. Biol., 37: 402-405.
    Direct Link  |  


  161. Ramya, R., J. Anudeepa, C. Senthilkumar, S.S. Rajendran, R. Sivasakthi, C. Moorthy and D.R. Venkatnarayanan, 2011. Wound healing activity of Dodonea viscosa Linn ointment in rats. Int. J. Res. Pharm. Chem., 1: 481-483.
    Direct Link  |  


  162. Madhavan, V., H. Basnett, M.R. Gurudeva and S.N. Yoganarasimhan, 2009. Pharmacognostical evaluation of Drosera burmannii Vahl (Droseraceae). Indian J. Tradit. Knowledge, 8: 326-333.
    Direct Link  |  


  163. Das, B., A. Dey, A.D. Talukdar, K. Nongalleima, M.D. Choudhury and L. Deb, 2014. Antifertility efficacy of Drynaria quercifolia (L.) J. Smith on female Wister albino rats. J. Ethnopharmacol., 153: 424-429.
    CrossRef  |  Direct Link  |  


  164. Arora, R.B., N. Ghatak and P.S. Gupta, 1971. Anti-fertility activity of Embelia ribes. J. Res. Indian Med., 6: 107-110.


  165. Radhakrishnan, N. and M. Alam, 1975. Antifertility activity of embelin in albino rats. Indian J. Exp. Biol., 13: 70-71.
    Direct Link  |  


  166. Rathinam, K., G. Santhakumari and N. Ramiah, 1976. Studies on the antifertility activity of embelin. J. Res. Ind. Med. Yoga Homeop., 11: 84-90.
    Direct Link  |  


  167. Kholkute, S.D., M.B. Kekare, V.S. Jathar and S.R. Munshi, 1978. Antifertility effects of Embelia ribes Burm. Indian J. Exp. Biol., 16: 1035-1037.
    PubMed  |  


  168. Prakash, A.O. and R. Mathur, 1979. Studies on oestrous cycle of albino rats: Response to Embelia ribes extracts. Planta Med., 36: 134-141.
    CrossRef  |  Direct Link  |  


  169. Krishnaswamy, M. and K.K. Purushothaman, 1980. Antifertility properties of Embelia ribes. Indian J. Exp. Biol., 18: 638-639.
    PubMed  |  


  170. Krishnaswamy, M. and K.K. Purushothaman, 1980. Antifertility properties of Embelia ribes: (embelin). Indian J. Exp. Biol., 18: 1359-1360.
    PubMed  |  


  171. Prakash, A.O., 1981. Antifertility investigations on Embelin-an oral contraceptive of plant origin. Part I-Biological properties. Planta Medica, 41: 259-266.
    CrossRef  |  PubMed  |  Direct Link  |  


  172. Bhargava, S.K., V.P. Dixit and P. Khanna, 1984. Antifertility effect of embelin in female rats. Fitoterapia, 55: 302-304.
    Direct Link  |  


  173. Wango, E.O., 2005. Anti-fertility effects of embelin in female Sprague-Dawley rats may be due to suppression of ovarian function. Acta Biologica Hungarica, 56: 1-9.
    CrossRef  |  Direct Link  |  


  174. Dutta, N.K., M.Y. Mhasalkar and G.R. Fernando, 1970. A study on the antifertility action of VIDR-2GD: A constituent isolated from the seeds of Ensete superbum, Cheesm, Musaceae (Banakadali). Fertil. Steril., 21: 247-252.
    PubMed  |  Direct Link  |  


  175. Keshri, G., V. Lakshmi, M.M. Singh and V.P. Kamboj, 1999. Post-coital antifertility activity of Ferula assafoetida extract in female rats. Pharmaceut. Biol., 37: 273-276.
    CrossRef  |  Direct Link  |  


  176. Keshri, G., M. Bajpai, V. Lakshmi, B.S. Setty and G. Gupta, 2004. Role of energy metabolism in the pregnancy interceptive action of Ferula assafoetida and Melia azedarach extracts in rat. Contraception, 70: 429-432.
    CrossRef  |  Direct Link  |  


  177. Homady, M.H., K.M. Khleifat, K.A. Tarawneh and I.A. Al-Raheil, 2002. Reproductive toxicity and infertility effect of Ferula hormonis extracts in mice. Theriogenology, 57: 2247-2256.
    CrossRef  |  Direct Link  |  


  178. Prakash, A.O., S. Pathak and R. Mathur, 1991. Postcoital contraceptive action in rats of a hexane extract of the aerial parts of Ferula jaeschkeana. J. Ethnopharmacol., 34: 221-234.
    CrossRef  |  Direct Link  |  


  179. Prakash, A.O. and S. Jonathan, 1996. Effect of hexane extract of Ferula jaeschkeana on the reproductive organs in cyclic female rats. Philippine J. Sci., 125: 129-146.
    Direct Link  |  


  180. Prakash, A.O. and S. Pathak, 1994. Inhibition of β-glucuronidase activity in rat uterus during implantation by feeding Ferula jaeschkeana extract. Int. J. Pharm., 32: 362-365.
    CrossRef  |  Direct Link  |  


  181. Prakash, A.O. and M. Sharma, 1997. Morphological and functional consequences in the reproductive organs of immature rats exposed to multiple admnistration of Ferula jaeschkeana extract. Phytother. Res., 11: 1-5.
    Direct Link  |  


  182. Sharma, R.K., A.K. Goyal and R.A. Bhat, 2013. Antifertility activity of plants extracts on female reproduction: A review. Int. J. Pharm. Biol. Sci., 3: 493-514.
    Direct Link  |  


  183. Akpantah, A.O., A.A. Oremosu, C.C. Noronha, T.B. Ekanem and O.A. Okanlawon, 2005. Effects of Garcinia kola seed extract on ovulation, oestrous cycle and foetal development in cyclic female sprague-dawley rats. Niger. J. Physiol. Sci., 20: 58-62.
    PubMed  |  Direct Link  |  


  184. Ratnasooriya, W.D., G.A.S. Premakumara and L.M.V. Tillekeratne, 1994. Post-coital contraceptive activity of crude extracts of Sri Lankan marine red algae. Contraception, 50: 291-299.
    CrossRef  |  Direct Link  |  


  185. Premakumara, G.A.S., W.D. Ratnasooriya and L.M.V. Tillekeratne, 1995. Studies on the post-coital contraceptive mechanisms of crude extract of Sri Lankan marine red algae, Gelidiella acerosa. Contraception, 52: 203-207.
    CrossRef  |  Direct Link  |  


  186. Elbetieha, A., S.A. Oran, A. Alkofahi, H. Darmani and A.M. Raies, 2000. Fetotoxic potentials of Globularia arabica and Globularia alypum (Globulariaceae) in rats. J. Ethnopharmacol., 72: 215-219.
    CrossRef  |  Direct Link  |  


  187. Latha, K.P., H. Kirana and H.N. Girish, 2013. Anti-implantation activity of the hydroalcoholic tuber extract of Gloriosa superba Linn in female albino rats. Int. J. Adv. Pharm. Biol. Chem., 2: 443-448.
    Direct Link  |  


  188. Lin, Y.C., T. Fukaya, Y. Rikihisa and A. Walton, 1985. Gossypol in female fertility control: Ovum implantation and early pregnancy inhibited in rats. Life Sci., 37: 39-47.
    CrossRef  |  Direct Link  |  


  189. Offiah, V.N. and C.E. Ezenwaka, 2003. Antifertility properties of the hot aqueous extract of Guaiacum officinale. Pharmaceut. Biol., 41: 454-457.
    CrossRef  |  Direct Link  |  


  190. Prakash, A.O., R.B. Gupta and R. Mathur, 1978. Effect of oral administration of forty two indigenous plant extracts on early and late pregnancy in albino rats. Probe, 27: 315-323.


  191. Kabir, S.N., K. Bhattacharya, A.K. Pal and A. Pakrashi, 1984. Flowers of Hibiscus rosa-sinensis, a potential source of contragestative agent: I. Effect of benzene extract on implantation of mouse. Contraception, 29: 385-397.
    CrossRef  |  Direct Link  |  


  192. Pal, A.K., K. Bhattacharya, S.N. Kabir and A. Pakrashi, 1985. Flowers of Hibiscus rosa-sinensis, a potential source of contragestative agent: II. Possible mode of action with reference to anti-implantation effect of the benzene extract. Contraception, 32: 517-529.
    CrossRef  |  PubMed  |  Direct Link  |  


  193. Nivsarkar, M., M. Patel, H. Padh, C. Bapu and N. Shrivastava, 2005. Blastocyst implantation failure in mice due to nonreceptive endometrium: Endometrial alterations by Hibiscus rosa-sinensis leaf extract. Contraception, 71: 227-230.
    CrossRef  |  PubMed  |  Direct Link  |  


  194. Vasudeva, N. and S.K. Sharma, 2008. Post-coital antifertility activity of Hibiscus rosa-sinensis Linn. roots. Evidence-Based Complement. Altern. Med., 5: 91-94.
    CrossRef  |  Direct Link  |  


  195. Saluja, A.K. and D.D. Santani, 1983. Hormonal properties of Hyptis suaveolens roit. Indian J. Pharmacol., 45: 97-99.


  196. Hyacinth, A.A. and U.C. Nwocha, 2011. Antifertility activity of aqueous ethanolic extract of Hymenocardia acida stem bark in female rats. Iran. J. Reprod. Med., 9: 217-222.
    Direct Link  |  


  197. Al-Dissi, N.M., A.S. Salhab and H.A. Al-Hajj, 2001. Effects of Inula viscosa leaf extracts on abortion and implantation in rats. J. Ethnopharmacol., 77: 117-121.
    CrossRef  |  Direct Link  |  


  198. Dabhadkar, D. and V. Zade, 2013. Abortifacient efficacy of Indigofera trifoliata leaves extract on female albino rats. Asian J. Pharm. Clin. Res., 6: 75-79.
    Direct Link  |  


  199. Mishra, A., J.V.V. Dogra, J.N. Singh and O.P. Jha, 1979. Post-coital antifertility activity of Annona squamosa and Ipomoea fistulosa. Planta Medica, 35: 283-285.
    CrossRef  |  Direct Link  |  


  200. Dhar, J.D., B.S. Shetty, K. Singh, S. Jain and D.S. Bhakuni, 1993. Contraceptive potential of Ischinochiton camptus. Biol. Memories, 19: 95-99.


  201. Singh, M.M., S.R. Chowdhury, D.K. Kulshreshtha and V.P. Kamboj, 1993. Antigestagenic activity of Ixora finlaysoniana in rat. Contraception, 48: 178-191.
    CrossRef  |  Direct Link  |  


  202. Goonasekera, M.M., V.K. Gunawardana, K. Jayasena, S.G. Mohammed and S. Balasubramaniam, 1995. Pregnancy terminating effect of Jatropha curcas in rats. J. Ethnopharmacol., 47: 117-123.
    CrossRef  |  Direct Link  |  


  203. Jain, S., G.P. Choudhary and D.K. Jain, 2013. Pharmacological evaluation and antifertility activity of Jatropha gossypifolia in rats. BioMed Res. Int.
    CrossRef  |  Direct Link  |  


  204. Agrawal, O.P., S. Bharadwaj and R. Mathur, 1980. Antifertility effects of fruits of Juniperus communis. Planta Medica, 40: 98-101.
    CrossRef  |  Direct Link  |  


  205. Aswal, B.S., D.S. Bhakuni, A.K. Goel, K. Kar, B.N. Mehrotra and K.C. Mukherjee, 1984. Screening of Indian plants for biological activity: Part X. Indian J. Exp. Biol., 22: 312-332.
    PubMed  |  Direct Link  |  


  206. Elujoba, A.A., S.O. Olagbende and S.K. Adesina, 1985. Anti-implantation activity of the fruit of Lagenaria breviflora Robert. J. Ethnopharmacol., 13: 281-288.
    CrossRef  |  PubMed  |  Direct Link  |  


  207. Agunu, A., C. Samagoro and H. Nuhu, 2011. Evaluation of the anti-fertility of Lawsonia inermis L. roots found in Kaduna State, Nigeria. Proceedings of the 59th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research, September 4-9, 2011, Antalya, Turkey -


  208. Munshi, S.R., T.A. Shetye and R.K. Nair, 1977. Antifertility activity of three indigenous plant preparations. Planta Medica, 31: 73-75.
    CrossRef  |  Direct Link  |  


  209. Tafesse, G., Y. Mekonnen and E. Makonnen, 2005. In vivo and in vitro anti-fertility and anti-implantation properties of Leonotis ocymifolia in rats. Afr. J. Tradit. Complement. Altern. Med., 2: 103-112.
    Direct Link  |  


  210. Singh, M.M., V. Wadhwa, D.N. Gupta, R. Pal, N.M. Khanna and V.P. Kamboj, 1984. Postcoital contraceptive efficacy and hormonal profile of Lepidium capitatum. Planta Medica, 50: 154-157.
    CrossRef  |  PubMed  |  Direct Link  |  


  211. Gaitonde, B.B. and R.T. Mahajan, 1980. Antifertility activity of Lygodium flexuosum. Indian J. Med. Res., 72: 597-604.


  212. Thakur, S.C., S.S. Thakur, S.K. Chaube and S.P. Singh, 2005. An etheral extract of Kamala (Mallotus philippinensis (Moll. Arg) Lam.) seed induce adverse effects on reproductive parameters of female rats. Reprod. Toxicol., 20: 149-156.
    CrossRef  |  Direct Link  |  


  213. Dixit, V.P., 1977. Effect of chronically administered Malvaviscus conzattii flower extract on the female genital tract of gerbil, Merionis hurrianae, Jerdon. Indian J. Exp. Biol., 15: 1650-1652.


  214. Banerjee, R., A.K. Pal, S.N. Kabir and A. Pakrashi, 1999. Antiovulatory faculty of the flower of Malvaviscus conzattii. Phytother. Res., 13: 169-171.
    CrossRef  |  Direct Link  |  


  215. Chowdhury, A.K.A., M.F. Hashim, B.C. Sen, O.F. Khan and M. Ahmed, 1994. Antifertility principles from Marsdenia tinctoria: Pharmacological and phytochemical studies. Pure Applied Chem., 66: 2343-2346.
    CrossRef  |  Direct Link  |  


  216. Montanari, T. and E. Bevilacqua, 2002. Effect of Maytenus ilicifolia Mart. on pregnant mice. Contraception, 65: 171-175.
    CrossRef  |  Direct Link  |  


  217. Keshri, G., V. Lakshmi and M.M. Singh, 2003. Pregnancy interceptive activity of Melia azedarach Linn. in adult female Sprague-Dawley rats. Contaception, 68: 303-306.
    CrossRef  |  PubMed  |  Direct Link  |  


  218. Mandal, R. and P.K. Dhaliwal, 2007. Antifertility effect of Melia azedarach Linn. (dharek) seed extract in female albino rats. Indian J. Exp. Biol., 45: 853-860.
    PubMed  |  Direct Link  |  


  219. Bodhankar, S.L., S.K. Garg and V.S. Mathur, 1974. Antifertility screening of plants. Part IX. Effect of five indigenous plants on early pregnancy in female albino rats. Indian J. Med. Res., 62: 831-837.
    PubMed  |  Direct Link  |  


  220. Kapoor, M., S.K. Garg and V.S. Mathur, 1974. Anthiovulatory activity of five indigenous plants in rabbits. Indian J. Med. Res., 62: 1225-1227.
    PubMed  |  


  221. Kanjanapothi, D., Y. Smitasiri, A. Panthong, T. Taesotikul and V. Rattanapanone, 1981. Postcoital antifertility effect of Mentha arvensis. Contraception, 24: 559-567.
    CrossRef  |  Direct Link  |  


  222. Taprial, S., D. Kashyap, V. Mehta, S. Kumar and D. Kumar, 2013. Antifertility effect of hydroalcoholic leaves extract of Michelia champaca L.: An ethnomedicine used by Bhatra women in Chhattisgarh state of India. J. Ethnopharmacol., 147: 671-675.
    CrossRef  |  Direct Link  |  


  223. Ganguly, M., N. Devi, R. Mahanta and M.K. Borthakur, 2007. Effect of Mimosa pudica root extract on vaginal estrous and serum hormones for screening of antifertility activity in albino mice. Contraception, 76: 482-485.
    CrossRef  |  PubMed  |  Google  |  


  224. Aguwa, C.N. and G.C. Mittal, 1983. Abortifacient effects of the roots of Momordica angustisepala. J. Ethnopharmacol., 7: 169-173.
    CrossRef  |  Direct Link  |  


  225. Sharanabasappa, A., B. Vijayakumar and S.B. Patil, 2002. Effect of Momordica charantia seed extracts on ovarian and uterine activities in albino rats. Pharm. Biol., 40: 501-507.
    CrossRef  |  Direct Link  |  


  226. Ifeanyi, A.C., Y.O. Eboetse, D.F. Ikechukwu, O.A. Adewale, N.C. Carmel and O.A. Olugbenga, 2011. Effect of Momordica charantia on estrous cycle of Sprague-Dawley rats. Pac. J. Med. Sci., 8: 37-48.


  227. Koneri, R., R. Balaraman and C.D. Saraswati, 2006. Antiovulatory and abortifacient potential of the ethanolic extract of roots of Momordica cymbalaria Fenzl in rats. Indian J. Pharmacol., 38: 111-114.
    CrossRef  |  Direct Link  |  


  228. Koneri, R., C.D. Saraswati, R. Balaraman and E.A. Ajeesha, 2007. Antiimplantation activity of the ethanolic root extract of Momordica cymbalaria Fenzl in rats. Indian J. Pharamacol., 39: 90-96.
    CrossRef  |  Direct Link  |  


  229. Pedron, N., A.V. Estrada, H. Ponce-Monter, A. Valencia, A. Guzman and A.J. Gallegos, 1985. The Zoapatle VII. Antiimplantation effect in the rat of Zoapatle Aqueous Crude Extract (ZACE) from Montanoa tomentosa and Montanoa frutescenes. Contraception, 31: 499-507.
    CrossRef  |  Direct Link  |  


  230. Perusquia, M., E. Sanchez, H. Ponce-Monter, A.V. Estrada and N. Pedron et al., 1985. The Zoapatle XI. Effects elicited by Mmontanoa tomentosa and Montanoa frutescens on rat uterine strips. Contraception, 31: 543-551.
    CrossRef  |  Direct Link  |  


  231. Landgren, B.M., A.R. Aedo, K. Hagenfeldt and E. Diczfalusy, 1979. Clinical effects of orally administered extracts of Montanoa tomentosa in early human pregnancy. Am. J. Obstetr. Gynecol., 135: 480-484.
    CrossRef  |  Direct Link  |  


  232. Hahn, D.W., E.W. Ericson, M.T. Lai and A. Probst, 1981. Antifertility activity of Montanoa tomentosa (Zoapatle). Contraception, 23: 133-140.
    PubMed  |  Direct Link  |  


  233. Waller, D.P., A. Martin, Y. Oshima and H.H.S. Fong, 1987. Studies on Zoapatle V. correlation between in vitro uterine and in vivo pregnancy interruption effects in guinea pigs. Contraception, 35: 147-153.
    CrossRef  |  Direct Link  |  


  234. Shukla, S., R. Mathur and A.O. Prakash, 1988. Antifertility profile of the aqueous extract of Moringa oleifera roots. J. Ethnopharmacol., 22: 51-62.
    CrossRef  |  Direct Link  |  


  235. Dhawan, B.N., M.P. Dubey, B.N. Mehrotra, R.P. Rastogi and J.S. Tandon, 1980. Screening of Indian plants for biological activity: Part IX. Indian J. Exp. Biol., 18: 594-606.
    PubMed  |  Direct Link  |  


  236. Zade, V., S. Pare, D. Dabhadkar and R. Chondekar, 2010. Abortifacient efficacy of Moringa oleifera in albino rats. Int. J. Pharmacol. Biol. Sci., 4: 133-138.
    Direct Link  |  


  237. Kong, Y.C., K.H. Ng, K.H. Wat, A. Wong and I.F. Saxena et al., 1985. Yuehchukene, a novel anti-implantation indole alkaloid from Murraya paniculata. Planta Medica, 51: 304-307.
    CrossRef  |  Direct Link  |  


  238. Soni, P., A.A. Siddiqui, J. Dwivedi and V. Soni, 2013. Antiovulatory and estrogenic activity of stem of Musa paradisiaca in female albino rats. J. Applied Pharmaceut. Sci., 3: 102-106.
    Direct Link  |  


  239. Mazumder, U.K., M. Gupta, G. Pramanik, R.K. Mukhopadhyay and S. Sarkar, 1992. Antifertility activity of seed of Nelumbo nucifera in mice. Indian J. Exp. Biol., 30: 533-534.
    PubMed  |  


  240. Mutreja, A., M. Agarwa, S. Kushwaha and A. Chauhan, 2008. Effect of Nelumbo nucifera seeds on the reproductive organs of female rats. Int. J. Reprod. BioMed., 6: 7-11.
    Direct Link  |  


  241. Keshri, G., M.M. Singh, V. Lakshmi and V.P. Kamboj, 1995. Post-coital contraceptive efficacy of the seeds of Nigella sativa in rats. Indian J. Physiol. Pharmacol., 39: 59-62.
    Direct Link  |  


  242. Khanna, S., S.R. Gupta and J.K. Grover, 1986. Effect of long term feeding of tulsi (Ocimum sanctum Linn) on reproductive performance of adult albino rats. Indian J. Exp. Biol., 24: 302-304.
    PubMed  |  Direct Link  |  


  243. Batta, S.K. and G. Santhakumari, 1970. The antifertility effect of Ocimum sanctum and Hibiscus cosa sinensis. Indian J. Med. Res., 59: 777-781.
    Direct Link  |  


  244. Sripriya, S., G. Yuvaraj, R.K. Nema, V. Madhan Kumar and M. Deecaraman, 2011. Evaluation of antifertility activity from stem part of Ocimum gratissimum in acetone extracts. Int. J. Pharmaceut. Clin. Res., 3: 41-44.
    Direct Link  |  


  245. Patil, S.J. and S.B. Patil, 2012. Effect of Oxalis corniculata whole plant extracts on fertility regulation in female Albino rats. J. Adv. Scient. Res., 3: 58-61.
    Direct Link  |  


  246. Shapira, Z., J. Terkel, Y. Egozi, A. Nyska and J. Friedman, 1989. Abortifacient potential for the epigeal parts of Peganum harmala. J. Ethnopharmacol., 27: 319-325.
    CrossRef  |  Direct Link  |  


  247. Sadik, G., M.A. Gafur, M.S.A. Bhuiyan, A.H.M.K. Alam and M.H.U. Biswas et al., 2001. Antifertility activity of Pergularia daemia. J. Med. Sci., 1: 22-24.
    CrossRef  |  Direct Link  |  


  248. Sadik, M.G., M.A. Gafur, M.S.A. Bhuiyan, M.M. Rahman and H.U. Biswas, 2001. Antifertility activity of the alkaloidal fraction of Pergularia daemia. J. Med. Sci., 1: 217-219.
    CrossRef  |  Direct Link  |  


  249. Rao, M.V. and K.M. Alice, 2001. Contraceptive effects of Phyllanthus amarus in female mice. Phytother. Res., 15: 265-267.
    CrossRef  |  Direct Link  |  


  250. Montaserti, A., M. Pourheydar, M. Khazaei and R. Ghorbani, 2007. Anti-fertility effects of Physalis alkekengi alcoholic extract in female rat. Iranian J. Reprod. Med., 5: 13-16.
    Direct Link  |  


  251. Sudhakaran, S., B. Ramanathan and A. Ganapathi, 1999. Antifertility effects of the petroleum ether extract of Physalis minima on female albino rats. Pharmaceut. Biol., 37: 269-272.
    CrossRef  |  Direct Link  |  


  252. Stolzenberg, S.J., R.M. Parkhurst and E.J. Reist, 1976. Blastocidal and contraceptive actions by an extract and compounds from Endod (Phytolacca dodecandra). Contraception, 14: 39-51.
    CrossRef  |  Direct Link  |  


  253. Sharma, J.D., L. Sharma and P. Yadav, 2007. Antifertility efficacy of Piper betle Linn. (Petiole) on female albino rats. Asian J. Exp. Sci., 21: 145-150.
    Direct Link  |  


  254. Short, R.E., L.F. James, K.E. Pantert, R.B. Staigmiller, R.A. Bellows, J. Malcolm and S.P. Ford, 1992. Effects of feeding ponderosa pine needles during pregnancy: Comparative studies with bison, cattle, goats and sheep. J. Anim. Sci., 70: 3498-3504.
    CrossRef  |  Direct Link  |  


  255. Short, R.E., S.P. Ford, E.E. Grings and S.L. Kronberg, 1995. Abortifacient response and plasma vasoconstrictive activity after feeding needles from ponderosa pine trees to cattle and sheep. J. Anim. Sci., 73: 2102-2104.
    CrossRef  |  Direct Link  |  


  256. Lakshmi, V., R. Kumar, S.K. Agarwal and J.D. Dhar, 2006. Antifertility activity of Piper longum Linn. in female rats. Nat. Prod. Res., 20: 235-239.
    CrossRef  |  Direct Link  |  


  257. Lal, R., A. Sankaranarayanan and V.S. Mathur, 1983. Antifertility and uterine activity of Plumbago rosea in rats. Indian J. Med. Res., 78: 287-290.
    PubMed  |  


  258. Sheeja, E., S.B. Joshi and D.C. Jain, 2008. Antifertility activity of stems of Plumbago rosea in female albino rats. Pharmaceut. Biol., 46: 920-927.
    CrossRef  |  Direct Link  |  


  259. Sattar, M.A., N.A. Abdullah, A.H. Khan, A. Dewa and D. Samshia, 2007. Uterotrophic, fetotoxic and abortifacient effect of a Malaysian variety of Plumbago rosea L. on isolated rat uterus and pregnant mice. Pak. J. Biol. Sci., 10: 763-767.
    CrossRef  |  PubMed  |  Direct Link  |  


  260. Sheeja, E., S.B. Joshi and D.C. Jain, 2009. Antiovulatory and estrogenic activity of Plumbago rosea leaves in female albino rats. Indian J. Pharmacol., 41: 273-277.
    CrossRef  |  Direct Link  |  


  261. Edwin, S., S.B. Joshi and D.C. Jain, 2009. Antifertility activity of leaves of Plumbago zeylanica Linn. in female albino rats. Eur. J. Contracept. Reprod. Health Care, 14: 233-239.
    CrossRef  |  PubMed  |  Direct Link  |  


  262. Sandeep, G., A. Dheeraj, N.K. Sharma, D. Jhade and A. Bharti, 2011. Effect of plumbagin free alcohol extract of Plumbago zeylanica Linn. root on reproductive system of female Wistar rats. Asian Pac. J. Trop. Med., 4: 978-984.
    CrossRef  |  Direct Link  |  


  263. Dabhadkar, D. and V. Zade, 2012. Abortifacient activity of Plumeria rubra (Linn) pod extract in female albino rats. Indian J. Exp. Biol., 50: 702-707.
    Direct Link  |  


  264. Kholkute, S.D., S.R. Munshi, S.D. Naik and V.S. Jathar, 1978. Antifertility activity of indigenous plants Sida carpinifolia Linn. and Podocarpus brevifolius Stapf in female rats. Indian J. Exp. Biol., 16: 696-698.
    PubMed  |  


  265. Hazarika, A. and H.N. Sarma, 2007. Effects of crude root extract of Polygonum hydropiper on estrous cycle and induction of reversible sterility in female albino rat. J. Endocrinol. Reprod., 11: 36-40.
    Direct Link  |  


  266. Londonkar, R.L. and H.B. Nayaka, 2011. Evaluation of anti implantation and abortificient properties of Portulaca oleracea L. in albino rats. Int. J. Pharma Bio Sci., 2: 501-508.
    Direct Link  |  


  267. Nayak, H.B., R.L. Londonkar and M.K. Umesh, 2014. Evaluation of potential antifertility activity of total flavonoids, isolated from Portulaca oleracea L. on female albino rats. Int. J. PharmTech Res., 6: 783-793.
    Direct Link  |  


  268. Trisomboon, H., S. Malaivijitnond, G. Watanabe and K. Taya, 2005. Ovulation block by Pueraria mirifica: A study of its endocrinological effect in female monkeys. Endocrine, 26: 33-39.
    CrossRef  |  Direct Link  |  


  269. Sharma, K.C. and S.S.K. Shanmugasundaram, 1979. An antifertility drug from ethnobotanical folklore. Regional Res. Lab. Jammu Newslet., 6: 5-12.
    Direct Link  |  


  270. Chandhoke, N., O.P. Gupta, C.K. Atal and J.G. Langer, 1981. Clinical evaluation of Pueraria tuberose for its contraceptive emmonaggue activity. Indian J. Pharmacol., 13: 60-65.


  271. Prakash, A.O., V. Saxena, S. Shukla and R. Mathur, 1985. Contraceptive potency of Pueraria tuberosa D.C. and its hormonal status. Acta Europaea Fertilitatis, 16: 59-65.
    PubMed  |  


  272. Pillai, N.R., M. Alam and K.K. Purushothaman, 1977. Studies on the antifertility activity of oleanolic acid 3-β-glucoside (RDG-1). J. Res. Indian Med. Yoga Homeopath., 12: 26-29.
    Direct Link  |  


  273. Onu, U.O., 1995. Evaluation of the folklore use of Rhaptopetalum coriaceum olio as an abortifacient. Phytother. Res., 9: 64-65.
    CrossRef  |  Direct Link  |  


  274. Rasheed, R.A., A.K. Bashir, B.H. Ali and R. Padmanabhan, 1997. Effect of Rhazya stricta on the developing rat fetus. Reprod. Toxicol., 11: 191-199.
    CrossRef  |  Direct Link  |  


  275. Makonnen, E., L. Zerihun, G. Assefa and A.A. Rostom, 1999. Antifertility activity of Ricinus communis seed in female guinea pigs. East Afr. Med. J., 76: 335-337.
    PubMed  |  


  276. Sani, U.M. and M.I. Sule, 2007. Anti-fertility activity of methanol extracts of three different seed varieties of Ricinus communis Linn (Euphorbiaceae). Niger. J. Pharmaceut. Sci., 6: 78-83.
    Direct Link  |  


  277. Shivalingappa, H., N.D. Satyanarayan and M.G. Purohit, 2001. Antiimplantation and pregnancy interruption efficacy of Rivea hypocrateriformis in the rat. J. Ethnopharmacol., 74: 245-249.
    CrossRef  |  PubMed  |  Direct Link  |  


  278. Shivalingappa, H., N.D. Satyanarayan, M.G. Purohit, A. Sharanabasappa and S.B. Patil, 2002. Effect of ethanol extract of Rivea hypocrateriformis on the estrous cycle of the rat. J. Ethnopharmacol., 82: 11-17.
    CrossRef  |  Direct Link  |  


  279. Gebrie, E., E. Makonnen, A. Debella and L. Zerihun, 2005. Phytochemical screening and pharmacological evaluations for the antifertility effect of the methanolic root extract of Rumex steudelii. J. Ethnopharmacol., 96: 139-143.
    CrossRef  |  Direct Link  |  


  280. Gebrie, E., E. Makonnen, L. Zerihun and A. Debella, 2005. The possible mechanisms for the antifertility action of methanolic root extract of Rumex steudelii. Afr. Health Sci., 5: 119-125.
    PubMed  |  Direct Link  |  


  281. Kong, Y.C., C.P. Lau, K.H. Wat, K.H. Ng, P.P. But, K.F. Cheng and P.G. Waterman, 1989. Antifertility principle of Ruta graveolens. Planta Medica, 55: 176-178.
    CrossRef  |  PubMed  |  Direct Link  |  


  282. Gandhi, M., R. Lal, A. Sankaranarayanan and P.L. Sharma, 1991. Post-coital antifertility activity of Ruta graveolens in female rats and hamsters. J. Ethnopharmacol., 34: 49-59.
    CrossRef  |  Direct Link  |  


  283. Elbetieha, A., M.H. Al-Hamood, A. Alkofahi and H. Bataineh, 1998. Reproductive toxicity potentials of Salviafruticosa (Labiatae) in rats. J. Ethnopharmacol., 61: 67-74.
    CrossRef  |  Direct Link  |  


  284. Tu, Z.B., C. Konno, D.D. Soejarto, D.P. Waller and A.S. Bingel et al., 1988. Identification of senecionine and senecionine N-oxide as antifertility constituents in Senecio vulgaris. J. Pharmaceut. Sci., 77: 461-463.
    CrossRef  |  PubMed  |  Direct Link  |  


  285. Singh, S.P., 1990. Fertility control of female through Sesbania sesban seeds. J. Res. Educ. Indian Med., 9: 27-32.
    Direct Link  |  


  286. Lutterodt, G.D., 1988. Abortifacient properties of an extract from Sida veronicaefolia. J. Ethnopharmacol., 23: 27-37.
    CrossRef  |  Direct Link  |  


  287. Uchendu, C.N. and T. Isek, 2008. Antifertility activity of aqueous ethanolic leaf extract of Spondias mombin (Anacardiaceae) in rats. Afr. Health Sci., 8: 163-167.
    Direct Link  |  


  288. Jafarzadeh, L., M. Rafieian-Kopaei, R. Ansari Samani and A. Asgari, 2012. The effect of hydroalcoholic extract of Stachys lavandulifolia Vahl on pregnant mice. EXCLI J., 11: 357-362.
    Direct Link  |  


  289. Hiremath, S.P., S.H. Rao, P.K. Jain, Y. Jaya and K. Sembulingam, 1990. Antifertility activity of Striga lutea-Part I. Indian J. Physiol. Pharmacol., 34: 23-25.
    PubMed  |  


  290. Hiremath, S.P. and S.H. Rao, 1990. Antifertility efficacy of the plant Striga lutea (scropholariacae) on rats. Contraception, 42: 467-477.
    CrossRef  |  Direct Link  |  


  291. Hiremath, S.P., S. Badami, H.K.S. Swamy, S.B. Patil and R.L. Londonkar, 1994. Antifertility activity of Striga orobanchioides. Biol. Pharmaceut. Bull., 17: 1029-1031.
    CrossRef  |  Direct Link  |  


  292. Hiremath, S.P., S. Badami, S.K. Hunasagatta and S.B. Patil, 2000. Antifertility and hormonal properties of flavones of Striga orobanchioides. Eur. J. Pharmacol., 391: 193-197.
    CrossRef  |  Direct Link  |  


  293. Choudhury, M.K., U.M. Sani and A. Mustapha, 1998. Antifertility activity of the flowers of Striga senegalensis (Scrophulariaceae). Phytother. Res., 12: 207-208.
    CrossRef  |  Direct Link  |  


  294. Hsu, C.C., R.H. Dobberstein, A.S. Bingel, H.H.S. Fong, N.R. Farnsworth and J.F. Morton, 1981. Biological and phytochemical investigation of plants XVI: Strumpfia maritima (Rubiaceae). J. Pharmaceut. Sci., 70: 682-683.
    CrossRef  |  PubMed  |  Direct Link  |  


  295. Mukhram, M.A., H. Shivakumar, G.L. Viswanatha and S. Rajesh, 2012. Anti-fertility effect of flower extracts of Tabernaemontana divaricata in rats. Chin. J. Nat. Med., 10: 58-62.
    CrossRef  |  Direct Link  |  


  296. Jain, S., A. Jain, L. Deb, K.R. Dutt and D.K. Jain, 2010. Evaluation of anti-fertility activity of Tabernaemontana divaricata (Linn) R.Br. leaves in rats. Nat. Prod. Res., 24: 855-860.
    CrossRef  |  Direct Link  |  


  297. Mehrotra, P.K. and V.P. Kamboj, 1978. Hormonal profile of coronaridine hydrochloride-an antifertility agent of plant origin. Planta Medica, 33: 345-349.
    CrossRef  |  Direct Link  |  


  298. Srivastava, S., M.M. Singh and D.K. Kulshreshtha, 2001. A new alkaloid and other anti-implantation principles from Tabernaemontana heyneana. Planta Medica, 67: 577-579.
    CrossRef  |  PubMed  |  Direct Link  |  


  299. Tewari, P.V., C. Chaturvedi and S.N. Dixit, 1970. Antifertility effect of betal leaf stalk (Tambul patrabrint): A preliminary experimental study. J. Res. Indian Med., 4: 143-151.
    PubMed  |  


  300. Yadav, B.L., R. Mathur and R.B. Gupta, 1980. Antifertility activity of Terminalia arjuna (W&A) in female albino rats. Probe, 19: 196-198.


  301. Vishwanatha, T., S. Satishagouda, S.J. Patil and B.S. Patil, 2009. Anti-implantation activity of Terminalia bellirica bark extracts in female albino rats. Biotechnol. Indian J., 3: 257-260.


  302. Kavimani, S., R. Ilango, R. Karpagam, K. Suryaprabha and B. Jaykar, 1999. Anti-oestrogenic activity of floral extract of Thespesia populnea Corr. in mouse ovary. Indian J. Exp. Biol., 37: 1241-1242.
    Direct Link  |  


  303. Ghosh, K. and T.K. Bhattacharya, 2004. Preliminary study on the antiimplantation activity of compounds from the extracts of seeds of Thespesia populnea. Ind. J. Pharmacol., 36: 288-291.
    Direct Link  |  


  304. Joshi, G.C. and M. Gopal, 2011. Antifertility activity of hexane and ethyl acetate extracts of aerial parts of Tragia involucrate Linn. J. Pharmacol. Toxicol., 6: 548-553.
    CrossRef  |  Direct Link  |  


  305. Pare, S., V. Zade and D. Dabhadkar, 2013. Evaluation of potential antifertility activity of plant Trianthema portulacastrum in female albino rat. Int. J. Applied Pharm. Sci. Biomed. Sci., 2: 7-11.


  306. Kage, D.N., V.B. Malashetty, Y.N. Seetharam, P. Suresh and S.B. Patil, 2009. Effect of ethanol extract of whole plant of Trichosanthes cucumerina var. Cucumerina L. on gonadotropins, ovarian follicular kinetics and estrous cycle for screening of antifertility activity in albino rats. Int. J. Morphol., 27: 173-182.
    CrossRef  |  Direct Link  |  


  307. Ng, T.B., W.Y. Chan, L.Y. Sze and H.W. Yeung, 1991. Trichosanthin induces atresia of ovarian follicles and inhibits steroidogenesis in gonadotropin-primed immature mice. Gen. Pharmacol., 22: 847-849.
    PubMed  |  Direct Link  |  


  308. Yadav, R., 1988. Studies on natural products of certain medicinal plants. Ph.D. Thesis, University of Rajasthan, Jaipur.


  309. Sharma, J.D. and A. Bhinda, 2005. Anti-fertility activity of steroidal extract of Trigonella foenum-graceum (seeds) in female rats. Asian J. Exp. Sci., 19: 115-120.
    Direct Link  |  


  310. Kassem, A., A. Al-Aghbari, M. Al-Habori and M. Al-Mamary, 2006. Evaluation of the potential antifertility effect of fenugreek seeds in male and female rabbits. Contraception, 73: 301-306.
    CrossRef  |  Direct Link  |  


  311. Dande, P. and S. Patil, 2012. Evaluation of saponins from Trigonella foenum graecum seeds for its antifertility activity. Asian J. Pharmaceut. Clin. Res., 5: 154-157.
    Direct Link  |  


  312. Yao, M., H.E. Ritchie and P.D. Brown-Woodman, 2007. A developmental toxicity-screening test of valerian. J. Ethnopharmacol., 113: 204-209.
    CrossRef  |  Direct Link  |  


  313. Dhall, K. and M. Dhogra, 1988. Phase I and II clinical trials with Vicoa indica (Banjauri), a herbal medicine, as an antifertility agent. Contraception, 37: 75-84.
    CrossRef  |  PubMed  |  Direct Link  |  


  314. Rao, A.J., N. Ravindranath and N.R. Moudgal, 1996. The plant Banjauri (Vicoa indica) exhibits antifertility activity in adult female bonnet monkeys (Macaca radiata). Curr. Sci., 71: 918-921.
    Direct Link  |  


  315. Pakrashi, A., B. Basak and N. Mookerji, 1975. Search for antifertility agents from indigenous medicinal plants. Indian J. Med. Res., 63: 378-381.
    Direct Link  |  


  316. Khushalani, H.N., P.A. Tatke and K.K. Singh, 2008. Antimicrobial activity of dried flowers of Woodfordia fruticosa Kurz. Asian J. Microbiol. Biotechnol. Environ. Sci., 10: 155-156.
    Direct Link  |  


  317. Keshri, G., S. Kumar, D.K. Kulshreshtha, S.M. Rajendran and M.M. Singh, 2008. Postcoital interceptive activity of Wrightia tinctoria in Sprague-Dawley rats: A preliminary study. Contraception, 78: 266-270.
    CrossRef  |  Direct Link  |  


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