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Journal of Pharmacology and Toxicology
  Year: 2011 | Volume: 6 | Issue: 5 | Page No.: 548-553
DOI: 10.3923/jpt.2011.548.553
Antifertility Activity of Hexane and Ethyl Acetate Extracts of Aerial Parts of Tragia involucrata. Linn
G. Chandrashekhar Joshi and M. Gopal

Abstract:
Many people in rural Bangladesh use a traditional contraceptive pill, “Shanti Bori” to control fertility in which Tragia involucrata is one of the components. The aim of the present study was to evaluate the validity of antifertility effect of this plant. The hexane (HE) and ethyl acetate extracts (EAE) of the aerial parts of T. involucrata have been evaluated for the anti-fertility activity in proven fertile female rats at dose of 200 mg kg-1 body weight. Preliminary phytochemical analysis showed the presence of phytosterols, triterpenes and flavonoids in the extracts. HE and EAE showed significant anti-fertility activity. It was found that the extracts reduced the number of litters born significantly at the dose of 200 mg kg-1 body weight. HE and EAE exhibited 81 and 50% antiimplantation potency respectively at the tested dose. The extracts also showed the estrogenic activity and potentiated the action of the standard drug ethanyl estradiol. All these observations suggest that extracts have antiimplantation as well as the abortifacient activity and are safe at the effective antifertility doses employed in this study.
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How to cite this article:

G. Chandrashekhar Joshi and M. Gopal, 2011. Antifertility Activity of Hexane and Ethyl Acetate Extracts of Aerial Parts of Tragia involucrata. Linn. Journal of Pharmacology and Toxicology, 6: 548-553.

DOI: 10.3923/jpt.2011.548.553

URL: https://scialert.net/abstract/?doi=jpt.2011.548.553

 
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