Simona Bratu
Division of Infectious Diseases, State University of New York-Downstate Medical Center,
Brooklyn, NY, USA
John Quale
Division of Infectious Diseases, State University of New York-Downstate Medical Center,
Brooklyn, NY, USA
ABSTRACT
Carbapenem antibiotics are typically reserved for serious nosocomial infections. Several classes of β-lactamases have emerged that possess carbapenem-hydrolyzing activity. Class A KPC-type β-lactamases have recently emerged in Klebsiella pneumoniae isolates from the northeastern United States. Class D OXA-type β-lactamases are typically found in Acinetobacter baumannii and Pseudomonas aeruginosa isolates from southern Europe. Class B metallo-β-lactamases are also typically found in A. baumannii and P. aeruginosa; regions in the Far East and Europe have been especially affected by bacteria carrying these enzymes. Most nosocomial pathogens that possess a carbapenem-hydrolyzing β-lactamases are frequently resistant to other classes of antibiotics, including aminoglycosides and fluoroquinolones. For infections caused by these highly resistant Gram-negative pathogens, polymyxin antibiotics are often administered, although concerns remain regarding their efficacy and toxicity.
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How to cite this article
Simona Bratu and John Quale, 2006. Global Emergence of Nosocomial Gram-negative Pathogens Possessing Carbapenem-hydrolyzing β-lactamases. Journal of Biological Sciences, 6: 434-445.
DOI: 10.3923/jbs.2006.434.445
URL: https://scialert.net/abstract/?doi=jbs.2006.434.445
DOI: 10.3923/jbs.2006.434.445
URL: https://scialert.net/abstract/?doi=jbs.2006.434.445
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