Simona Bratu
Division of Infectious Diseases, State University of New York,
Downstate Medical Center, Brooklyn, NY, USA
John Quale
Division of Infectious Diseases, State University of New York,
Downstate Medical Center, Brooklyn, NY, USA
ABSTRACT
Carbapenem antibiotics are typically reserved for serious nosocomial infections. Several classes of ß-lactamases have emerged that possess carbapenem-hydrolyzing activity. Class A KPC-type ß-lactamases have recently emerged in Klebsiella pneumoniae isolates from the northeastern United States. Class D OXA-type ß-lactamases are typically found in Acinetobacter baumannii and Pseudomonas aeruginosa isolates from southern Europe. Class B metallo-ß-lactamases are also typically found in A. baumannii and P. aeruginosa; regions in the Far East and Europe have been especially affected by bacteria carrying these enzymes. Most nosocomial pathogens that possess a carbapenem-hydrolyzing ß-lactamases are frequently resistant to other classes of antibiotics, including aminoglycosides and fluoroquinolones. For infections caused by these highly resistant Gram-negative pathogens, polymyxin antibiotics are often administered, although concerns remain regarding their efficacy and toxicity.
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How to cite this article
Simona Bratu and John Quale, 2006. Global Emergence of Nosocomial Gram-negative Pathogens Possessing Carbapenem-hydrolyzing ß-lactamases. Journal of Biological Sciences, 6: 220-230.
DOI: 10.3923/jbs.2006.220.230
URL: https://scialert.net/abstract/?doi=jbs.2006.220.230
DOI: 10.3923/jbs.2006.220.230
URL: https://scialert.net/abstract/?doi=jbs.2006.220.230
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