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Research Article
 
Analgesic and Anti-inflammatory Principle from Sida cordifolia Linn



Ranajit Kumar Sutradhar , AKM Matior Rahman , Mesbahuddin Ahmad , Sitesh Chandra Bachar and Achinto Saha.
 
ABSTRACT

A new flavonol glycoside, 3`-(3``,7``-dimethyl- 2``,6``-octadiene)-8-C-ß-D-glucosyl-kaempferol 3-O-ß-D-glucoside[1], isolated from Sida cordifolia Linn. was investigated for analgesic and anti-inflammatory activities in animal models. In the acetic acid induced writhing model, the drug at a dose of 25 and 50 mg kg-1 body weight showed statistically significant (p<0.0001) inhibition of writhing response of 25.12 and 52.30%, respectively. The drug also produced significant increase in the tail flick latency in a dose depended manner (r = 0.92) which were also statistically significant (p<0.0001). In carrageenan induced rat paw edema the compound produced 16.15 and 28.52% inhibition of paw edema at doses of 25 and 50 mg kg-1 body weight at the 3rd h of study.

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  How to cite this article:

Ranajit Kumar Sutradhar , AKM Matior Rahman , Mesbahuddin Ahmad , Sitesh Chandra Bachar and Achinto Saha. , 2006. Analgesic and Anti-inflammatory Principle from Sida cordifolia Linn. Journal of Biological Sciences, 6: 160-163.

DOI: 10.3923/jbs.2006.160.163

URL: https://scialert.net/abstract/?doi=jbs.2006.160.163

REFERENCES
Asha, B. and N.R. Bannerjee, 1985. Polarographic studies on active constituents of Sida cordifolia. Curr. Sci., 54: 690-692.

Chadha, Y.R., 1989. The Wealth of India. Vol. 9, Publications and Information Directorate, CSIR, New Delhi, pp: 323-324.

Chopra, R.N., K.L. Handa and L.D. Kapur, 1958. Chopras Indigenous Drugs of India. 2nd Edn., Academic Publishers, India, pp: 409.

Crunkhorn, P. and S.C.R. Meacock, 1971. Mediators of the inflammation induced in the rat paw by carrageenin. Br. J. Pharmacol., 42: 392-402.
CrossRef  |  PubMed  |  Direct Link  |  

D'Amour, F.E. and D.L. Smith, 1941. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther., 72: 74-79.
Direct Link  |  

Ghosh, S. and A. Dutt, 1930. Chemical examination of Sida cordifolia Linn. J. Ind. Chem. Soc., 7: 825-829.

Gunatilaka, A.A.L., S. Sotheeswaran, S. Balasubramaniam, A.I. Chandrasekara and H.T. Sriyani, 1980. Studies on medicinal plants of Sri Lanka. III. Pharmacologically important alkaloids of some sida species. Planta Med., 39: 66-72.
PubMed  |  

Kirtikar, K.R. and B.D. Basu, 1980. Indian Medicinal Plants. 2nd Edn., MP Singh and BP Singh, UK.

Ribeiro, R.A., M.L. Vale, S.M. Thomazzi, A.B.P. Paschoalato, S. Poole, S.H. Ferreira and F.Q. Cunha, 2000. Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur. J. Pharmacol., 387: 111-118.
CrossRef  |  PubMed  |  Direct Link  |  

Rosa, M.D. and D.A. Willoughby, 1971. Screens for anti inflammatory drugs. J. Pharm. Pharmacol., 23: 297-298.

Vinegar, R., W. Schreiber and R. Hugo, 1969. Biphasic development of carrageenin oedema in rats. J. Pharmacol. Exp. Therapeutics, 166: 96-103.
PubMed  |  Direct Link  |  

Vogel, H.G. and W.H. Vogel, 1997. Pharmacological Assays. Springer Verlag, Germany, pp: 368-370.

Voilley, N., 2004. Acid-Sensing Ion Channels (ASICs): New targets for the analgesic effects of Non-Steroid Anti-Inflammatory Drugs (NSAIDs). Curr. Drug Targets Inflamm. Allergy, 3: 71-79.
PubMed  |  Direct Link  |  

Whittle, B.A., 1964. The use of changes in capillary permeability in mice to distinguish between narcotic and non narcotic analgesics. Br. J. Pharmacol. Chemother., 22: 246-253.
Direct Link  |  

Winter, C.A., E.A. Risley and G.W. Nuss, 1962. Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Exp. Biol. Med., 111: 544-547.
CrossRef  |  PubMed  |  Direct Link  |  

Yusuf, M. and M. Kabir, 1999. Medicinal plants of Bangladesh. Bangladesh Council of Scientific and Industrial Research, Dhaka, Bangladesh, pp: 226.

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