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Journal of Biological Sciences

Year: 2006 | Volume: 6 | Issue: 6 | Page No.: 1098-1102
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Research Article

Immunohistochemical Study of Inducible Nitric Oxide and its Prognosis in Schistosomasis Associated Urinary Bladder Carcinoma

Attalla Farag El-Kott, Ezz Mohie El-Gamal and Abdalla Mohamed Khalil

ABSTRACT

The aim of this study was to examine iNOS expression in schistosomasis associated bladder carcinoma. iNOS expression was determined by immunohistochemisty. iNOS expression was found in almost 57.8% of bladder cancer patients. The significant correlation between the expression of iNOS and tumor parameters was present (p = 0.00948, 0.02702, 0.00013, 0.00006 and 10-6 for sex, tumor grades, tumor stage, DNA ploidy, lymph node status and tumor recurrence respectively. The overall survival for patient was 62.22% where the 5 year disease-specific survival was significantly with iNOS, tumor grade, tumor stage, DNA ploidy and lymph node status (p = 10-6, 0.0026, 0.0072, 0.0119 and 10-6, respectively). In multivariate analysis, the three markers, iNOS, tumor grade and lymph node status remained the prognostic in bladder cancer and the more significant was iNOS. Present results suggest that iNOS expression in schistosomasis associated urinary bladder carcinoma may predispose to cancer recurrences and confirm that iNOS could be considered a good prognostic factor.
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