Eleagnine, an alkaloid isolated from Chrysophyllum albidum seed cotyledon was investigated to evaluate its potential antinociceptive, anti-inflammatory and antioxidant activities. The antinociceptive effects were carried out using flick, hot-plate tests and acetic-acid induced writhings in mice. The anti-inflammatory activity and the pain threshold were assessed on the oedematous right hind paws of rats using plethysmometer and analgesiometer respectively. The antioxidant effect was carried out in vitro using DPPH (1,1-diphenyl-2-picrylhydrazyl) assay. The compound demonstrated potent analgesic (in all the four models used both peripheral and central sites), anti-inflammatory and a very weak antioxidant properties Naloxone (an opiod antagonist) showed that the analgesic effect was mediated through opiod transmission in both central and peripheral sites while its anti-inflammatory effect involve the inhibition of histamine, 5-HT, prostaglandins in carrageenan induced oedema. Antioxidant activity of the eleagnine ranges between 46.1 and 15.1% for the tested concentrations. This was far less than what observed for ascorbic acid. At much lower concentration. These pharmacological effects of this alkaloidal compound described here may suggest that eleagnine is one of the constituents of Chrysophyllum albidum responsible for the ethnomedical uses as antimicrobial agent through anti-inflammatory property.
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T.O. Idowu, E.O. Iwalewa, M.A. Aderogba, B.A. Akinpelu and A.O. Ogundaini, 2006. Antinociceptive, Anti-inflammatory and Antioxidant activities of Eleagnine: An alkaloid Isolated from Chrysophyllum albidum Seed Cotyledons. Journal of Biological Sciences, 6: 1029-1034.
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