Raffaella Franca
Istituto di Genetica Molecolare IGM-CNR, via Abbiategrasso 207, I-27100 Pavia, Italy
Silvio Spadari
Istituto di Genetica Molecolare IGM-CNR, via Abbiategrasso 207, I-27100 Pavia, Italy
Giovanni Maga
Istituto di Genetica Molecolare IGM-CNR, via Abbiategrasso 207, I-27100 Pavia, Italy
ABSTRACT
The HIV-1 Vif protein has been shown to counteract the antiviral activity of the cellular cytidine deaminase APOBEC3G. Based on several experimental evidences a paradigm has been established, stating that APOBEC3G is incorporated into newly formed viruses and deaminates the viral genome during the retrotranscription process following a new round of infection, leading to non-functional proviral DNA. Vif targets APOBEC3G in the virus producing cells and induces its degradation, thereby preventing its virion encapsidation. Recent findings, however, challenge this simplistic view and suggest that the biological roles of Vif and of APOBEC3G are far more complex and elusive than anticipated.
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How to cite this article
Raffaella Franca, Silvio Spadari and Giovanni Maga, 2005. Human Immunodeficiency Virus (HIV-1) Auxiliary Protein Vif and Cellular APOBEC Deaminases: Their Roles Unveiled?. Journal of Biological Sciences, 5: 855-863.
DOI: 10.3923/jbs.2005.855.863
URL: https://scialert.net/abstract/?doi=jbs.2005.855.863
DOI: 10.3923/jbs.2005.855.863
URL: https://scialert.net/abstract/?doi=jbs.2005.855.863
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