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Analysis of Blood for Secnidazole in Female Volunteers by HPLC Method



Suriya Bibi , Rakhshanda Nawaz , M. Nawaz , Muhammad Shahid and Sobia Qamar Kiani
 
ABSTRACT

The biokinetics parameters were investigated following oral dose of 1g secnidazole in healthy female volunteers. The plasma samples were deproteinized by ZnSO4 and NaOH analyzed by HPLC. The mean maximum concentration in plasma was found to be 23.08?0.8 after 2.5 h of drug administration. The area under curve (AUC) was 349.05 ± 20.9 h mg L-1. The clearance and volume of distribution were 0.44 ± 0.37 L h-1 and 11.09 ± 7.81 L respectively. The elimination half life was 13.86?0.92 h. The values for absorption rate constant and absorption half life were 2.97 ± 0.46 L h-1 and 0.27?0.03 h. The maximum concentration 16.24 ± 0.48 mg L-1 was achieved in 1.77 ± 0.16 h. These parameters showed that protein deproteinization method and analysis techniques are valid for the protein analysis of secnidazole.

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  How to cite this article:

Suriya Bibi , Rakhshanda Nawaz , M. Nawaz , Muhammad Shahid and Sobia Qamar Kiani , 2002. Analysis of Blood for Secnidazole in Female Volunteers by HPLC Method . Journal of Biological Sciences, 2: 769-770.

DOI: 10.3923/jbs.2002.769.770

URL: https://scialert.net/abstract/?doi=jbs.2002.769.770

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