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Diabetic Complications: Influence of Age, Sex, Family History, Duration, Glycemic Control and Obesity

Amjad Hameed , Salman Ahmad Malik , Fazli-Rabbi , Aysha Sharif , Nasir Ahmad , Farwa Nurjis , Shafaqat Ali and Javed Anver Qureshi

This study was undertaken to find prevalence of diabetic complications and influence of age, sex, family history, duration, glycemic control and obesity on these complications in 1104 diabetic patients. Late diabetic complications were present in 76% cases. The prevalence of hypertension was 28.846%, retinopathy 25.962%, neuropathy 24.038%, nephropathy and ischemic heart disease 8.654%, polyarthritis 6.731%, angina and urinary track infection 5.769%, dermatitis 4.808% and atherosclerosis 1.923%. Overall 74% cases had poor glycemic control. An increase in mean (SD) (227.722 (74.521) vs. 222.360 (64.386) mg/dl) and most frequent (mode) (340 vs. 200 mg/dl) random blood glucose of complicated cases compared with non complicated cases was observed. There was no difference in mean (SD) age (50.768 (13.715) vs. 50.800 (12.845) years) and median age (50 vs. 50 years) of complicated and non-complicated cases while most frequent age (mode) (45 vs. 40 years) was higher in complicated cases. The mean (SD) (43.240 (12.965) vs. 46.760 (13.694) years), median (43 vs. 49 years) and most frequent age at diagnosis of diabetes (mode) (40 vs. 46 years) was lower in complicated cases compared with non-complicated cases. The prevalence of diabetic complications was low (66.667%) in diabetic patients with family history of diabetes as compared to diabetic patients without family history of diabetes (79.221%). An increased percentage of complicated cases in males (80.33%) as compared to female patients (72.09%) were observed. Mean (SD) duration of diabetes was higher in complicated diabetic patients (7.585 (5.730) years) as compared to non-complicated diabetic patients (4.080 (4.551) years). There was an increase in percent-complicated cases with an increase in duration of diabetes and both parameters showed a positive regression (R2 = 0.84). Obese diabetic patients have 13.555 and 14.461% more chance of developing diabetic complications compared with normal and lean diabetic patients respectively. It was concluded that poor glycemic control, early age at diagnosis, gender (male), duration of diabetes and obesity are the factors which can increase the risk of developing diabetic complications.

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  How to cite this article:

Amjad Hameed , Salman Ahmad Malik , Fazli-Rabbi , Aysha Sharif , Nasir Ahmad , Farwa Nurjis , Shafaqat Ali and Javed Anver Qureshi , 2002. Diabetic Complications: Influence of Age, Sex, Family History, Duration, Glycemic Control and Obesity . Journal of Biological Sciences, 2: 710-714.

DOI: 10.3923/jbs.2002.710.714


Alberti, K.G.M.M. and P.Z. Zimmet, 1998. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabetic Med., 15: 539-553.
CrossRef  |  PubMed  |  Direct Link  |  

Alessandro, D., Y. Yang, M.M. Alecki, S. Scotti and J. Dreyfus, 1999. Phenotypic characteristics of early onset autosomal dominant type 2 diabetes unlinked to known maturity onset diabetes of the young genes. Diabetes Care, 22: 253-261.

Antonio, J.A., D. Ellis, B.H. Doft, D.J. Becker, A.L. Drash, L.H. Kuller and T.J. Orchard, 1995. Diabetes complications and glycemic control. The Pittsburgh prospective insulin-dependent diabetes cohort study status report after 5 year of IDDM. Diabetes Care, 12: 694-700.

Black, S.A., P.L. Jakobi, R.D. Rush, A.R. Dinuzzo and D. Garcia, 1999. Ethnic variation in the health burden of self-reported diabetes in adults aged 75 and older. Ethnic Dis., 9: 22-32.

Cohen, J.A., B.W. Jeffers, D. Faldut, M. Marcoux and R.W. Schrier, 1998. Risks for sensorimotor peripheral neuropathy and autonomic neuropathy in non-insulin-dependent diabetes mellitus (NIDDM). Muscle Nerve, 21: 72-80.

DCCT Research Group, 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med., 329: 977-986.
CrossRef  |  PubMed  |  Direct Link  |  

Delamater, A.M., K.H. Shaw, E.B. Applegate, I.A. Pratt and M. Eidson et al., 1999. Risk for metabolic control problems in minority youth with diabetes. Diabetes Care, 22: 700-705.

Ehtisham, S., T.G. Barrett and N.J. Shaw, 2000. Type 2 diabetes mellitus in UK children: An emerging problem. Diabetic Med., 17: 867-871.

Ford, M.E., B.C. Tilley and P.E. McDonald, 1998. Social support among African-American adults with diabetes. Part 1: Theoretical Framework. J. Natl. Med. Assoc., 90: 361-365.

Gaillard, T.R., D.P. Schuster and K. Osei, 1998. Gender differences in cardiovascular risk factors in obese, nondiabetic first-degree relatives of African Americans with type 2 diabetes mellitus. Ethnic Dis., 8: 319-330.

Gu, K., C.C. Conie and M.I. Harris, 1998. Mortality in adults with and with out diabetes in a national cohort of the US population. Diabetes Care, 21: 1138-1145.

Haffner, S.M., R.J.D. Agostino, L. Mykkanen, R. Tracy and B. Howard et al., 1999. Insulin sensitivity in subjects with type 2 diabetes. Relationship to cardiovascular risk factors: The insulin resistance atherosclerosis study. Diabetes Care, 22: 562-568.

Haider, Z., S. Obaidullah and K. Maqbool, 1980. Hypertension in Pakistani patients with diabetes mellitus. J. Trop. Med. Hyg., 83: 251-253.

Harris, M.I., 1998. Diabetes in America: Epidemiology and scope of the problem. Br. J. Dermatol., 139: 665-671.

Hawthorne, K. and S. Tomlinson, 1999. Pakistani moslems with Type 2 diabetes mellitus: Effect of sex, literacy skills, known diabetic complications and place of care on diabetic knowledge, reported self-monitoring management and glycaemic control. Diabetic Med., 16: 591-597.

Khan, A.J., 1991. Prevalence of diabetic retinopathy in Pakistani subjects: A pilot study. J. Pak. Med. Assoc., 41: 49-50.

Levitt, N.S., D. Bradshaw, M.F. Zwarenstein, A.A. Bawa and S. Maphumolo, 1997. Audit of public sector primary diabetes care in Cape Town, South Africa: High prevalence of complications, uncontrolled hyperglycaemia and hypertension. Diabetic Med., 12: 1073-1077.

Lloyd, G., 1991. Psychiatry. In: Davidson`s Principles and Practice of Medicine, Edwards, C. and I. Bouchier (Eds.). Longman Group, UK., pp: 958-959.

Mangia, A., G. Schiavone, G. Lezzi, R. Marmo and F. Bruno et al., 1998. HCV and diabetes mellitus: Evidence for a negative association. Am. J. Gastroenterol., 93: 2363-2367.

Motala, A.A., F.J. Pirie, E. Gouws, A. Amod and M.A. Omar, 2001. Microvascular complications in South African patients with long-duration diabetes mellitus. S. Afr. Med. J., 91: 987-992.

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