Subscribe Now Subscribe Today

How Much Chronic Exposure to Aluminum and its Toxicity Should be Concerned in Current Human Life?

Asieh Hosseini

Not available

Related Articles in ASCI
Similar Articles in this Journal
Search in Google Scholar
View Citation
Report Citation

  How to cite this article:

Asieh Hosseini , 2011. How Much Chronic Exposure to Aluminum and its Toxicity Should be Concerned in Current Human Life?. International Journal of Pharmacology, 7: 675-676.

DOI: 10.3923/ijp.2011.675.676

Received: May 19, 2011; Accepted: June 20, 2011; Published: September 09, 2011

From the earliest days of food and environment regulation, the use of Aluminum (Al) in foods and water has been condemned. Al is an environmentally abundant metal entering various food additives and medicines which accumulates in the organism body (Pournourmohammadi et al., 2008). Al has been suggested as a toxic agent in several pathological processes, including neurodegenerative diseases, mycrocytic anemia and osteoporosis (Mohammadirad and Abdollahi, 2011). Al causes its chronic toxicity through oxidative stress by generating reactive free radicals and disruption of cellular lipids, proteins and DNA. Generally, oxidative stress represents an imbalance between the production of reactive oxygen species and a biological system's capability to cleanse free radical intermediates or to repair the induced damages to cell wall and its nucleus. In the body, there are antioxidants that act against oxidants including non-enzymatic and enzymatic types. Non-enzymatic antioxidants include vitamins like C and E, seleniun, zinc, glutathione, uric acid and ubiquinol. Enzymatic antioxidants include Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GPx) (Abdollahi et al., 2004). Therefore, the evaluation of oxidative stress has become an important aspect of investigation of Al toxicity (Malekirad et al., 2010).

Recently, Mohammadirad and Abdollahi (2011) conducted a systematic review on Al and evaluated studies on oxidant/antioxidant imbalance induced by Al toxicity. They concluded that disruption of balance between body oxidant and antioxidant system plays a predominant role in Al toxicity, although they stated that exact mechanism of Al toxicity is not yet known. In the recent years, involvement of oxidative stress in the pathogenesis of many diseases including inflammatory bowel diseases (Rezaie et al., 2007; Hosseini-Tabatabaei and Abdollahi, 2008), diabetes (Rahimi et al., 2005), osteoporosis (Yousefzadeh et al., 2006) and other oxidant-related diseases (Hasani-Ranjbar et al., 2009, 2010; Ranjbar et al., 2008) has been described.

As is often the case, these findings raise new concerns. For instance, if human life is inevitably exposed to environmental Al and if Al acts through oxidative stress and if oxidative stress is involved in pathogenesis of many human debilitating diseases, thus we have to expect involvement of Al in pathogenesis of much more diseases. Proving human exposure to Al by means of measuring its blood concentration and finding sources of Al exposure in the life of people suffering from debilitating diseases and then exploring the link between disease incidence and severity with exposure to Al will lead us to better definition of human diseases and their prognosis. Fortunately, Al has antidote that if used in proper time and dosage can control toxicity of Al (Nikfar et al., 2011), if the source of exposure ends. Taking collectively, exposure to Al is an important concern in the present industrial life of human.

Abdollahi, M., A. Ranjbar, S. Shadnia, S. Nikfar and A. Rezaie, 2004. Pesticides and oxidative stress: A review. Med. Sci. Monit., 10: RA141-RA147.
PubMed  |  Direct Link  |  

Hasani-Ranjbar, S., B. Larijani and M. Abdollahi, 2009. A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases. Inflamm. Allergy Drug Targets, 8: 2-10.
PubMed  |  Direct Link  |  

Hasani-Ranjbar, S., N. Nayebi, B. Larijani and M. Abdollahi, 2010. A systematic review of the efficacy and safety of Teucrium species; from anti-oxidant to anti-diabetic effects. Int. J. Pharmacol., 6: 315-325.
CrossRef  |  Direct Link  |  

Hosseini-Tabatabaei, A. and M. Abdollahi, 2008. Potassium channel openers and improvement of toxic stress: Do they have role in the management of inflammatory bowel disease? Inflamm. Allergy Drug Targets, 7: 129-135.
Direct Link  |  

Malekirad, A.A., S. Oryan, A. Fani, V. Babapor and M. Hashemi et al., 2010. Study on clinical and biochemical toxicity biomarkers in a zinc-lead mine workers. Toxicol. Ind. Health, 26: 331-337.
CrossRef  |  PubMed  |  Direct Link  |  

Mohammadirad, A. and M. Abdollahi, 2011. A systematic review on oxidant/antioxidant imbalance in aluminum toxicity. Int. J. Pharmacol., 7: 12-21.
CrossRef  |  Direct Link  |  

Nikfar, S., M. Khatibi, A. Abdollahi-Asl and M. Abdollahi, 2011. Cost and utilization study of antidotes: An Iranian experience. Int. J. Pharmacol., 7: 46-49.
CrossRef  |  Direct Link  |  

Pournourmohammadi, S., P. Khazaeli, S. Eslamizad, A. Tajvar, A. Mohammadirad and M. Abdollahi, 2008. Study on the oxidative stress status among cement plant workers. Hum. Exp. Toxicol. 27: 463-469.
CrossRef  |  Direct Link  |  

Rahimi, R., S. Nikfar, B. Larijani and M. Abdollahi, 2005. A review on the role of antioxidants in the management of diabetes and its complications. Biomed. Pharmacother., 59: 365-373.
PubMed  |  Direct Link  |  

Ranjbar, A., K. Khani-Jazani, A. Sedighi, F. Jalali-Mashayekhi, M. Ghazi-Khansari and M. Abdollahi, 2008. Alteration of body total antioxidant capacity and thiol molecules in human chronic exposure to aluminum. Toxicol. Environ. Chem., 90: 707-713.
CrossRef  |  Direct Link  |  

Rezaie, A., R.D. Parker and M. Abdollahi, 2007. Oxidative stress and pathogenesis of inflammatory bowel disease: An epiphenomenon or the cause. Dig. Dis. Sci., 52: 2015-2021.
CrossRef  |  PubMed  |  

Yousefzadeh, G., B. Larijani, B. Mohammadirad R. Heshmat, G. Dehghan, R. Rahimi and M. Abdollahi, 2006. Determination of oxidative stress status and concentration of TGF-β1 in the blood and saliva of osteoporotic subjects. Ann. N. Y. Acad. Sci., 1091: 142-150.
CrossRef  |  Direct Link  |  

©  2020 Science Alert. All Rights Reserved