M. H. Al-Nazawi
Department of Physiology, Biochemistry and Pharmacology,
College of Veterinary Medicine and Animal Resources, King Faisal University, P.O. Box 3498, Al-Ahsa 31982, Saudi Arabia
A. M. Homeida
Department of Physiology, Biochemistry and Pharmacology,
College of Veterinary Medicine and Animal Resources, King Faisal University, P.O. Box 3498, Al-Ahsa 31982, Saudi Arabia
ABSTRACT
Intravenous administration of sulphadimidine (SDM) at a dose of 50 mg kg-1 body weight as a single-dose or repeated-dose treatments to lactating camels resulted in residues of SDM and its metabolite N4-acetyl in milk. Milking twice daily resulted in depletion of SDM and N4-acetyl residue during a withdrawal period of 5 days after the last injection of the drug. Milk protein binding and concentration of metabolite was very low suggesting that monitoring of sulphonamide residues in milk could be limited to SDM alone.
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How to cite this article
M. H. Al-Nazawi and A. M. Homeida, 2005. Residues of Sulphadimidine and its Metabolite N4-acetyl in Camel Milk. International Journal of Pharmacology, 1: 249-251.
DOI: 10.3923/ijp.2005.249.251
URL: https://scialert.net/abstract/?doi=ijp.2005.249.251
DOI: 10.3923/ijp.2005.249.251
URL: https://scialert.net/abstract/?doi=ijp.2005.249.251
REFERENCES
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CrossRef - Al-Nazawi, M.H., 2005. Pharmacokinetics and tolerance of thiamphenicol in camels and sheep. Int. J. Pharmacol., 1: 25-28.
CrossRefDirect Link