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International Journal of Pharmacology

Year: 2005 | Volume: 1 | Issue: 3 | Page No.: 244-248
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Research Article

Pharmacokinetics of Chloramphenicol in Healthy and Water-deprived Goats

E.U. Etuk and P.A. Onyeyili

ABSTRACT

A comparative pharmacokinetic study of chloramphenicol (25 mg kg-1 intravenous) by Chemical assay in normal and water-deprived Sokoto red goats revealed that the plasma drug concentrations were significantly higher in water-deprived goats. Various pharmacokinetic parameters like Area Under the Curve (AUC), half- life of elimination (t½β) were significantly lower whereas the total body clearance (Cl) and elimination rate constant (β) were significantly higher in water-deprived goats as compared to normal goats. The mean resident time of the drug also increased from six to nine hours after water deprivation. The higher mean plasma concentration of the drug after water deprivation obtained in the study may indicate the need to reduce the dose of this drug in dehydrated patients to avoid dose-dependent toxicity.
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