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Research Journal of Immunology
  Year: 2008 | Volume: 1 | Issue: 1 | Page No.: 1-9
DOI: 10.3923/rji.2008.1.9
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Inhibition of Immediate-Type Allergic Reaction by 4-Arylcoumarin
Thongchai Taechowisan, Chunhua Lu, Yuemao Shen and Saisamorn Lumyong

We studied the effect of 4-Arylcoumarin (5,7-dimethoxy-4-p-methoxyphenylcoumarin; MPC) on immediate-type allergic reaction and inflammatory cytokine secretion. MPC inhibited compound 48/80-induced systemic reactions in mice. When MPC was given as pretreatment, at concentrations ranging from 0.001 to 1 g kg1, the serum histamine levels induced by compound 48/80 were reduced in a dose-dependent manner. In addition, MPC also inhibited the passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody dose dependently. Furthermore, MPC decreased the phorbol 12-myristate 13-acetate plus calcium ionophore A23187-stimulated tumor necrosis factor-α and interleukin-6 secretion in human mast cells. These results indicate that MPC may be beneficial in the treatment of immediate-type allergic reactions.
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How to cite this article:

Thongchai Taechowisan, Chunhua Lu, Yuemao Shen and Saisamorn Lumyong, 2008. Inhibition of Immediate-Type Allergic Reaction by 4-Arylcoumarin. Research Journal of Immunology, 1: 1-9.

DOI: 10.3923/rji.2008.1.9








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